生物加工过程2023，Vol.21Issue(6)：589-598,10.DOI:10.3969/j.issn.1672-3678.2023.06.001
用于动态调控的响应启动子在合成生物学中的应用进展
Application of response promoters for dynamic regulation in synthetic biology
摘要
Abstract
With the development of metabolic engineering and synthetic biology,microorganisms,as cell factories,play an important role in the production of bio-based monomers,drug precursors and amino acids.Compared with traditional chemical synthesis and extraction of natural products from plants and animals,cell factories can greatly reduce environmental pollution and preserve natural resources.Meanwhile,dynamic regulation serves as a new strategy of metabolic engineering,which can not only control the timely distribution and redirection of metabolic flow,but also modulate microbial growth,metabolism and application.Regarding the application of dynamic regulation,response promoter acts as one of the most important components.In this review,we outlined recent development and principle of dynamic regulatory systems,then summarized the structure and regulatory mechanism of response promoters,as well as their types,characteristics and applications.We also presented the challenges and outlook for the potential applications of response promoters.关键词
合成生物学/代谢工程/动态调控/响应启动子/生物制造/群体感应Key words
synthetic biology/metabolic engineering/dynamic control/response promoter/bio-manufacture/quorum sensing分类
生物学引用本文复制引用
马定,高思远,王昕,陈可泉..用于动态调控的响应启动子在合成生物学中的应用进展[J].生物加工过程,2023,21(6):589-598,10.基金项目
国家重点研发计划(2021YFC2100800) （2021YFC2100800）
国家自然科学基金(U21B2097) （U21B2097）
