生物技术通报2023，Vol.39Issue(11)：123-136,14.DOI:10.13560/j.cnki.biotech.bull.1985.2023-0750
基于转运蛋白工程提升微生物菌株耐受性和生物制造效率的研究进展
Research Progress in the Improvement of Microbial Strain Tolerance and Efficiency of Biological Manufacturing Based on Transporter Engineering
摘要
Abstract
Microbial cell factories have been extensively used for sustainable production of biofuels,as well as high value and bulk chemicals.However,high concentration products or substrates,as well as stressful conditions during industrial production,may compromise fermentation efficiency and decreasing economics of production.In this context,microbial stress tolerance is crucial for green and sustainable production of the target products.In recent years,the use of transporters to protect microbial cells from toxic compounds for enhancing strain tolerance has received increasing worldwide attention.This review summarizes the progress of studies on microbial strain tolerance enhancement based on transporter engineering,analyses the current key points in the field of transporter research and discusses strategies to enhance strain tolerance based on transporter manipulation.Especially,the review highlights the applications of artificial intelligence in transporter annotation,structure simulation and substrate-transporter interaction prediction,aiming to promote the application of microorganisms in biological manufacturing.关键词
绿色生物制造/转运蛋白/胁迫耐受性/工业微生物/发酵效率Key words
green biological manufacturing/membrane transporter/stress tolerance/industrial microorganism/fermentation efficiency引用本文复制引用
李昕悦,周明海,樊亚超,廖莎,张风丽,刘晨光,孙悦,张霖,赵心清..基于转运蛋白工程提升微生物菌株耐受性和生物制造效率的研究进展[J].生物技术通报,2023,39(11):123-136,14.基金项目
国家重点研发计划(2022YFE0108500) （2022YFE0108500）
