生物技术通报2023，Vol.39Issue(11)：137-149,13.DOI:10.13560/j.cnki.biotech.bull.1985.2023-0686
微生物酸胁迫耐受性能强化的研究进展
Research Advances in the Enhancement of Microbial Tolerance to Acid Stress
摘要
Abstract
Microorganisms are often exposed to accumulation of various acidic substances during the fermentation process,which can seriously inhibit fermentation activity and production performance of the strains.Therefore,microorganisms have formed complex response mechanisms for the adaptation of low pH stress by coordinating cellular multiple physiological systems,metabolic pathways and regulatory network during the long-term evolution.The acid tolerance enhancement of the industrial microorganisms is a key way to improve its production efficiency.This review summarizes the recent research advances in the improvement on cell resistance to acids by the adaptive laboratory evolution,pre-adaptation,genome shuffling,genetic engineering,the global transcription machinery engineering,system biology and synthetic biology.The challenges and outlook of the relevant research are also discussed.关键词
微生物/酸胁迫/耐受性强化/菌株改造/基因线路Key words
microorganisms/acid stress/tolerance enhancement/strain modification/gene circuit引用本文复制引用
胡锦超,王敏,沈文琦,徐超业,樊雅祺,卢浩宇,蒋雯杰,李世龙,晋洪晨,骆健美..微生物酸胁迫耐受性能强化的研究进展[J].生物技术通报,2023,39(11):137-149,13.基金项目
国家自然科学基金项目(32270135,21978220) （32270135,21978220）
