实用医学杂志2023，Vol.39Issue(21)：2822-2826,5.DOI:10.3969/j.issn.1006-5725.2023.21.022
全科诊疗模式结合度洛西汀治疗对纤维肌痛综合征患者心理状况、睡眠质量及血清细胞因子的影响
Effects of general practice mode combined with duloxetine on psychological status,sleep quality and serum cytokines in patients with fibromyalgia syndrome
摘要
Abstract
Objective The aim of this study was to investigate the effects of general practice mode combined with duloxetine on psychological status,sleep quality and serum inflammatory cytokines in patients with Fibromyalgia Syndrome(FMS).Methods A total of 105 FMS patients in Chengde Central Hospital from January 2019 to December 2021 were divided into the combined group(53 cases)and the control group(52 cases)by the random number table method.The two groups were treated with general practice mode combined with duloxetine or duloxetine alone.The single course of treatment lasted for 4 weeks.Their efficacy and safety were evaluated after 2 courses of intervention.Visual analogue scale(VAS),Hamilton Anxiety assessment scale(HAMA),Hamilton Depression Scale(HAMD)and Pittsburgh Sleep Quality Index(PSQI)were performed before and after treatment.The pain,psychological status and sleep quality of the patients were evaluated.Blood samples were taken to measure the serum levels of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1)and IL-6 before and after treatment.Results The total effective rate in the study group was 96.23%,which was higher than that in the control group(82.69%,P<0.05).Compared with those before treatment,VAS,HAMA,HAMD and PSQI scores,serum TNF-α,IL-1 and IL-6 levels in the two groups were all decreased after treatment,and those in the study group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(7.55%vs.19.23%,P>0.05).Conclusion General practice mode combined with duloxetine was safe and effective in the treatment of FMS,which could significantly relieve anxiety and depression of patients,improve their sleep quality,and reduce the level of serum inflammatory cytokines.关键词
纤维肌痛综合征/全科诊疗模式/度洛西汀/心理状况/睡眠质量/炎性细胞因子Key words
fibromyalgia syndrome/general practice mode/Suloxetine/psychological state/sleep quality/inflammatory cytokines分类
医药卫生引用本文复制引用
周志安,边树伟,李洋,李明,孟爱霞,张文慧..全科诊疗模式结合度洛西汀治疗对纤维肌痛综合征患者心理状况、睡眠质量及血清细胞因子的影响[J].实用医学杂志,2023,39(21):2822-2826,5.基金项目
承德市科技技术研究与发展计划项目(编号:202109A017) （编号:202109A017）
