中国组织工程研究2024，Vol.28Issue(17)：2625-2630,6.DOI:10.12307/2024.475
磷酸钙复合重组人骨形态发生蛋白2修复和重建胫骨感染性骨缺损
Calcium phosphate combined with recombinant human bone morphogenetic protein-2 in repair and reconstruction of tibial infectious bone defects
摘要
Abstract
BACKGROUND:Although the clinical application of Masquelet technology has achieved extensive success,the research on optimizing all aspects of Masquelet technology is still being carried out.The focus of doctors is to speed up bone healing and shorten bone healing time after bone grafting. OBJECTIVE:To observe the effect of calcium phosphate combined with recombinant human bone morphogenetic protein-2 in repairing tibial infectious bone defects. METHODS:Thirty-one patients with tibial infectious bone defects were selected from The People's Hospital of Jianyang City from June 2017 to June 2022.They were treated with the Masquelet membrane induction technique.During the second stage of operation,they were divided into a control group(n=15)and a study group(n=16)according to different bone graft materials.Patients in the control group were implanted with autologous bone/allogeneic bone particles,and those in the study group were implanted with calcium phosphate combined with recombinant human bone morphogenetic protein-2/autologous bone particles.Six months after the second stage operation,peripheral blood inflammatory indexes such as white blood cell count,C-reactive protein,and erythrocyte sedimentation rate were detected.Imaging bone healing time,bone healing X-ray score,bone defect healing classification,and adjacent joint function were recorded.The presence of nail track infection,implant absorption,pain,and infection in the bone extraction area were observed. RESULTS AND CONCLUSION:(1)White blood cell count,erythrocyte sedimentation rate,and C-reactive protein levels of the two groups 6 months after the second stage operation were significantly lower than those before the first stage operation(P<0.05).There was no significant difference in each index between the two groups(P>0.05).(2)Bone healing time in the study group was shorter than that in the control group(P<0.05).(3)The Samantha X-ray score of the study group 6 months after the second stage operation was higher than that of the control group(P<0.05).The excellent and good rate of bone defect healing and adjacent joint function of the study group was higher than that of the control group(P<0.05).There was no significant difference in the recurrence rate and complication rate between the two groups(P>0.05).(4)These findings indicate that the effect of calcium phosphate combined with recombinant human bone morphogenetic protein-2 during the second stage operation of the Masquelet membrane induction technique in the treatment of tibial infectious bone defect is good and safe.关键词
胫骨感染性骨缺损/诱导膜技术/自体骨/异体骨/磷酸钙/骨形态发生蛋白2/人工骨Key words
tibial infectious bone defect/Masquelet membrane induction technique/autogenous bone/allogeneic bone/calcium phosphate/bone morphogenetic protein-2/artificial bone分类
临床医学引用本文复制引用
贾叙锋,龙苗,黄光平,钟庆,张兆尧,齐宇新,田鹏,李萍,陈宇驰..磷酸钙复合重组人骨形态发生蛋白2修复和重建胫骨感染性骨缺损[J].中国组织工程研究,2024,28(17):2625-2630,6.基金项目
四川省医学科研课题计划项目(S20037),项目名称:PARP-1调控自噬流在丙泊酚减轻心肌细胞缺血/再灌注损伤中的作用研究,项目负责人:钟庆 （S20037）
四川省卫生和计划委员会科研课题项目(17PJ212),项目名称:3D打印技术在骨盆前环骨折微创化治疗中的应用价值研究,项目负责人:黄光平 （17PJ212）
成都市卫生简阳委员会科研课题项目(2020085),项目名称:简阳地区去细胞同种异体神经修复周围神经损伤(缺损)的临床疗效分析,项目负责人:张兆尧 Sichuan Medical Research Project,No.S20037(to ZQ) （2020085）
Scientific Research Project of Sichuan Provincial Health and Planning Commission,No.17PJ212(to HGP) （to HGP）
Scientific Research Project of Chengdu Jianyang Health Commission,No.2020085(to ZZY) （to ZZY）
