中国组织工程研究2024，Vol.28Issue(17)：2774-2781,8.DOI:10.12307/2024.366
宫腔粘连中水凝胶促内膜修复的研究与进展
Research and advance of hydrogel-promoted endometrial repair in intrauterine adhesions
摘要
Abstract
BACKGROUND:The key to preventing the recurrence of intrauterine adhesions is to reconstruct the endometrium with normal function.The latest breakthrough in the treatment of recurrent intrauterine adhesions in and outside China is the use of degradable materials to prepare hydrogels to prevent the recurrence of adhesions. OBJECTIVE:To review the research advance in hydrogel-promoted endometrial repair in intrauterine adhesions. METHODS:PubMed,Web of Science,China National Knowledge Infrastructure(CNKI),and WanFang databases were searched systematically,with the keywords"intrauterine adhesions,endometrial injury,endometrium regeneration,hydrogel"in Chinese and English.Relevant articles published in each database from January 1990 to March 2023 were collected. RESULTS AND CONCLUSION:In recent years,research on hydrogel-promoted endometrial repair in uterine adhesions in and outside China has made some progress and plays an important role in the prevention and treatment of intrauterine adhesions and the promotion of endometrial repair:(1)As an important carrier in tissue engineering,hydrogel itself has excellent biocompatibility,biodegradability and three-dimensional network structure,which can be better applied in the treatment of intrauterine adhesions.(2)The hydrogel-based carrier system can promote the proliferation and differentiation of endometrial epithelial cells by transporting drugs/biologics/stem cells,and restore normal uterine morphology to prevent adhesion recurrence.(3)Hyaluronic acid hydrogels can not only meet good biocompatibility,but also promote the proliferation and differentiation of endometrial epithelial cells,and will be hydrolyzed by corresponding enzymes in utero,without affecting the normal metabolism of the body.They are currently commonly used uterine anti-adhesion agents in the clinic and are also the most commonly used hydrogel carriers in tissue engineering research.(4)Poloxamer hydrogel with excellent temperature-sensitive properties can rapidly gelate into the body,quickly form a physical barrier,and can play a slow-release effect on carrying substances and provide a platform for cell growth/adhesion.(5)There are broad prospects for the preparation of therapeutic hydrogels using materials with different characteristics,such as temperature-sensitive hydrogels,pH-responsive hydrogels and photosensitive hydrogels,but there are still many problems to be solved,such as the safety of the hydrogel system,whether the degradation products cause immune reactions,and whether they have an impact on the normal body's menstrual period.A large number of animal experiments and clinical trials are needed to verify its safety and efficacy,and continuously improve the treatment strategy.关键词
宫腔粘连/水凝胶/修复/子宫内膜再生/生长因子/干细胞Key words
intrauterine adhesion/hydrogel/repair/endometrial regeneration/growth factor/stem cell分类
医药卫生引用本文复制引用
邬浩明,王瑶,陈圆梦,朱慧莉,李开南,熊成东,胡旭麟..宫腔粘连中水凝胶促内膜修复的研究与进展[J].中国组织工程研究,2024,28(17):2774-2781,8.基金项目
四川省自然科学基金(23NSFSC5880),项目负责人:胡旭麟 （23NSFSC5880）
成都市医学科研课题(2022004),项目负责人:胡旭麟 （2022004）
四川省卫生健康委员会医学科技项目(21PJ127),项目负责人:王瑶 （21PJ127）
成都市医学科研课题项目(2022291),项目负责人:王瑶 （2022291）
国家自然科学基金项目(81601258),项目负责人:朱慧莉 （81601258）
成都市科技项目(2021-YF05-01612-SN),项目负责人:朱慧莉 Natural Science Foundation of Sichuan Province,No.23NSFSC5880(to HXL) （2021-YF05-01612-SN）
Chengdu Medical Research Project,No.2022004(to HXL) （to HXL）
Medical Science and Technology Project of Sichuan Provincial Health Commission,No.21PJ127(to WY) （to WY）
Chengdu Medical Research Project,No.2022291(to WY) （to WY）
National Natural Science Foundation of China,No.81601258(to ZHL) （to ZHL）
Chengdu Science and Technology Project,No.2021-YF05-01612-SN(to ZHL) （to ZHL）
