现代医药卫生2023，Vol.39Issue(23)：3997-4000,4005,5.DOI:10.3969/j.issn.1009-5519.2023.23.008
血液透析患者血前蛋白转化酶枯草溶菌素9水平与心血管事件的关系
Relationship between proproteinconvertase subtilisin/kexin type 9 and cardiovascular events in hemodialvsis patients
摘要
Abstract
Objective To investigate the relationship between the level of proprotein convertase subtili-sin/kexin type 9(PCSK9)and the incidence of major adverse cardiovascular events(MACE)in hemodialysis(HD)patients.Methods A total of 129 patients who started HD from January 2019 to June 2020 were pro-spectively enrolled in this hospital.The baseline blood PCSK9 level was detected by enzyme-linked immu-nosorbent assay(ELISA),and the occurrence of MACE was recorded.Kaplan-Meier,Log-Rank test and Cox multivariate regression analysis were used to analyze the effect of PCSK9 on the incidence of MACE in HD pa-tients.Results The cumulative incidence of MACE events in patients with PCSK9 level≥83.84 ng/mL was higher than that in patients with PCSK9 level＜83.84 ng/mL(Log-Rank=17.95,P＜0.001).The patients with high PCSK9 level(≥83.84 ng/mL)and high low density lipoprotein cholesterol level(≥3.4 mmol/L)had the highest incidence of MACE accumulation(Log-Rank=20.06,P＜0.001).Cox multiple regression a-nalysis showed that PCSK9 level≥83.84 ng/mL was an independent risk factor for MACE[hazard ratio(HR)=2.628,95％confidence interval(95％CI)1.114-3.379,P=0.012].Conclusion The high PCSK9 level is associated with the high risk of MACE in HD patients,and the combination of low density lipoprotein cholesterol is more valuable in predicting MACE.关键词
血液透析/前蛋白转化酶枯草溶菌素9/主要不良心血管事件/血脂/低密度脂蛋白胆固醇Key words
Hemodialysis/Proproteinconvertase subtilisin/kexin type 9/Major adverse cardiovas-cular events/Blood lipid/Low density lipoprotein cholesterol分类
医药卫生引用本文复制引用
张丰萍,于乐,彭贵平..血液透析患者血前蛋白转化酶枯草溶菌素9水平与心血管事件的关系[J].现代医药卫生,2023,39(23):3997-4000,4005,5.基金项目
江西省卫生健康委员会科技计划项目(SKJP220217958). （SKJP220217958）
