现代医药卫生2023，Vol.39Issue(23)：4013-4017,5.DOI:10.3969/j.issn.1009-5519.2023.23.012
改良版预处理方案的自体造血干细胞移植治疗急性髓系白血病3例临床观察及文献复习
Clinical observation and literature review of three cases of acute myeloid leukemia treated by autologous hematopoietic stem cell transplantation with modified preconditioning protocol
摘要
Abstract
Objective To investigate the efficacy and survival effects of cladribine(CLAD)combined with cytarabine and BuCy pretreatment regimen on autologous hematopoietic stem cell transplantation in pa-tients with acute myeloid leukemia.Methods Patients with acute myeloid leukemia with complete remission and negative residual lesions were selected for autologous hematopoietic stem cell transplantation using CLAD combined with cytarabine and BuCy pretreatment regimen,and the therapeutic effect,transplantation compli-cations and prognosis were observed.Results The transplantation complications of three patients were mild and the hematopoietic reconstruction time was early.The continuous remission time of three patients was 25,20,12 months,respectively,and there was still no recurrence.Conclusion For adult patients with acute mye-loid leukemia,CLAD combined with cytarabine and BuCy pretreatment regimen can promote implantation,re-duce recurrence rate,and improve the overall quality of life of patients.关键词
克拉屈滨/急性髓系白血病/自体造血干细胞移植/病例报告Key words
Cladribine/Acute myeloid leukemia/Autologous hematopoietic stem cell transplanta-tion/Case report分类
医药卫生引用本文复制引用
杨嫄,敬承旺,张颖,罗綦,查涵,周晓露,廖云娅,李云龙..改良版预处理方案的自体造血干细胞移植治疗急性髓系白血病3例临床观察及文献复习[J].现代医药卫生,2023,39(23):4013-4017,5.基金项目
重庆市2022年度技术预见与制度创新项目(CSTB2022TFⅡ-OTX0072) （CSTB2022TFⅡ-OTX0072）
重庆市綦江区科技局资助项目(2022035). （2022035）
