刑事技术2023，Vol.48Issue(6)：577-583,7.DOI:10.16467/j.1008-3650.2023.0020
基于非目标筛查技术的甲基苯丙胺合成路线分析
Non-Targeted Profiling of Methamphetamine in China
摘要
Abstract
Based on gas chromatography mass spectrometry and multivariate analysis,non-targeted profiling of methamphetamine in China was established to deduce the synthetic routes.After optimizing analysis condition with gas chromatography mass spectrometry,following appropriate examination of all the peaks,32 impurities were selected as the specific components in seized methamphetamine samples.Unsupervised(principal component analysis,PCA;hierarchical cluster analysis,HCA)and supervised(orthogonal projections to latent structures-DA,OPLS-DA)techniques were employed for classifying the 190 MA seizures.The results of PCA,HCA and OPLS-DA were in good agreement and showed a good tool for analyzing seizures correlation and synthesis routes.The established non-targeted screening technology has the advantage of simple operation,high reliability,not needing standard materials of impurities and can provide informative support to crack down the methamphetamine-related crime.关键词
毒品/气相色谱-质谱联用/非目标筛查/甲基苯丙胺/合成路线Key words
illicit drug/gas chromatography mass spectrometry(GC-MS)/non-targeted screening/methamphetamine/synthesis routes引用本文复制引用
郑晓雨,赵彦彪,闻武,郑珲..基于非目标筛查技术的甲基苯丙胺合成路线分析[J].刑事技术,2023,48(6):577-583,7.基金项目
国家重点研发计划国家质量基础设施体系专项课题(2021YFF0602501) （2021YFF0602501）
国家自然科学基金青年基金项目(21806022) （21806022）
中央级公益性科研院所基本科研业务费专项资金项目(2018JB042) （2018JB042）
