烟草科技2023，Vol.56Issue(12)：98-105,8.DOI:10.16135/j.issn1002-0861.2023.0551
烟碱在帕金森病中的神经保护作用及其机制的研究进展
Research progress on neuroprotective effects of nicotine in Parkinson's disease and its mechanism
摘要
Abstract
To explore the research progress of real and potential protective effects of nicotine on Parkinson's disease(PD)patients,the current research status and progress of PD at home and abroad were elaborated from the aspects of the neurological targets of nicotine action in the central nervous system,its potential neuroprotective mechanisms,and corresponding clinical implications through literature review and comprehensive analysis.In addition,current clinical application methods of nicotine were compared,and their prospects and limitations on using nicotine in treating and managing PD symptoms were summarized.The results showed that:1)Nicotine acted mainly on nAChRs in the brain to regulate nervous system function,directly or indirectly promoting dopamine release and thus improving clinical symptoms in PD patients.2)Nicotine could exert its neuroprotective effects through anti-protein aggregation,anti-neuronal apoptosis and anti-inflammation of neurons.3)The preclinical and clinical use of nicotine mainly included subcutaneous injection,tablets,nicotine gum,and nasal spray.4)Nicotine showed broad application prospects in the treatment of PD disease,but its dosage and clinical efficacy still need to be further clarified and improved.The results of this review provide an update and research directions for further clinical application of nicotine as the basis for anti-PD drugs.关键词
吸烟/烟碱/帕金森病/神经保护/作用机制/临床应用Key words
Smoking/Nicotine/Parkinson's disease/Neuroprotective effect/Mechanism/Clinical application分类
轻工纺织引用本文复制引用
何雨,张歆悦,朱洲梅,祁飞燕,管莹,杨兴隆..烟碱在帕金森病中的神经保护作用及其机制的研究进展[J].烟草科技,2023,56(12):98-105,8.基金项目
国家自然科学基金地区基金资助项目"TMEM230/Erk1/2/Beclin-1信号通路调控自噬在PD发生发展中的作用和机制研究"(81960242) （81960242）
云南省基础研究计划面上项目"CHCHD2通过调控HSPD1/NLRP3炎性体信号通路介导的细胞凋亡促进帕金森病的机制研究"(202001AT070001) （202001AT070001）
云南中烟工业有限责任公司技术中心烟草与健康联合研究院开放基金资助项目"尼古丁介导SIRT6调控自噬在帕金森病中发挥神经保护作用"(2021539200340039). （2021539200340039）
