医学信息2023，Vol.36Issue(23)：22-29,8.DOI:10.3969/j.issn.1006-1959.2023.23.006
ECMO治疗急性呼吸窘迫综合征预后危险因素的Meta分析
Meta-analysis of Prognostic Risk Factors of ECMO in the Treatment of Acute Respiratory Distress Syndrome
摘要
Abstract
Objective To systematically evaluate the risk factors for the prognosis of extracorporeal membrane oxygenation in the treatment of acute respiratory distress syndrome.Methods The databases of PubMed,EMbase,Web of Science,Cochrane and CNKI were searched by computer to screen the related studies on the prognosis of ECMO in the treatment of ARDS.The retrieval time was from the establishment of the database to March 2022.Two researchers independently screened the literature,extracted the data and evaluated the included literature.The quality of the included literature was evaluated according to the bias risk assessment tool(NOS scale)of RCT,and the Revman5.4 statistical software provided by Cochrane International Collaboration was used for meta-analysis.Results A total of 31 literatures were included,including 5585 patients.The results of meta-analysis showed that immune dysfunction(OR=2.63,95％CI:1.84-3.76,P<0.000 01),mechanical ventilation time before ECMO(MD=2.19,95％CI:1.48-2.90,P<0.000 01),lactic acid concentration(MD=0.82,95％CI:0.32-1.31,P=0.001),SAPSⅡ score(MD=6.36,95％CI:4.01-8.71,P<0.000 01),APACHEⅡ score(MD=2.99,95％CI:1.88-4.11,P<0.000 01),SOFA score(MD=1.28,95％CI:0.92-1.64,P<0.000 01)and ECMO time(MD=1.93,95％CI:1.31-2.55,P<0.000 01)were negatively correlated with death.Conclusion Immune dysfunction,mechanical ventilation time before ECMO,lactic acid concentration,SAPSⅡ score,APACHEⅡ score,SOFA score and ECMO time are risk factors for the prognosis of ECMO in ARDS patients.关键词
体外膜肺氧合/急性呼吸窘迫综合征/SAPSⅡ评分/APACHEⅡ评分/SOFA评分Key words
Extracorporeal membrane oxygenation/Acute respiratory distress syndrome/SAPSⅡ score/APACHEⅡ score/SOFA score分类
医药卫生引用本文复制引用
康凤尔,姚杨,曹晓梅,宁林,丁格,王胜昱..ECMO治疗急性呼吸窘迫综合征预后危险因素的Meta分析[J].医学信息,2023,36(23):22-29,8.基金项目
1.2020年西安市第七批科技计划[编号:20YXYJ0001(7)] （7）
2.医学科研发展基金项目临床与基础研究专项(编号:B21021BN) （编号:B21021BN）
