摘要
Abstract
Objective To study the clinical effect and safety of domestic and imported insulin glargine in the treatment of diabetes mellitus.Methods A total of 62 diabetic mellitus patients diagnosed and treated in our hospital from January 2020 to August 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 31 patients in each group.The control group was treated with imported insulin glargine,and the observation group was treated with domestic insulin glargine.The clinical effects,blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)],blood glucose compliance time,insulin dose,incidence of hypoglycemia,incidence of adverse reactions and economic costs were compared between the two groups.Results The total effective rate of the observation group was 93.55%,which was lower than 96.77%of the control group,but the difference was not statistically significant(P＞0.05).After treatment,the levels of FPG,2 hPG and HbA1 c in the two groups were lower than those before treatment(P＜0.05),but there was no significant difference in blood glucose index between the observation group and the control group(P＞0.05).There was no significant difference in the time of blood glucose reaching the standard between the observation group and the control group(P＞0.05),but the insulin dose in the observation group was lower than that in the control group(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).The drug cost and total cost of treatment in the observation group were lower than those in the control group(P＜0.05).Conclusion Domestic insulin glargine can achieve similar therapeutic effect with imported insulin glargine in the treatment of diabetes mellitus,and domestic insulin glargine can improve blood glucose index,reduce insulin dose,reduce the incidence of adverse reactions,reduce drug costs and total treatment costs.关键词
国产甘精胰岛素制剂/进口甘精胰岛素制剂/糖尿病Key words
Domestic insulin glargine/Imported insulin glargine/Diabetes mellitus分类
医药卫生
