医学信息2023，Vol.36Issue(23)：165-169,5.DOI:10.3969/j.issn.1006-1959.2023.23.042
CNP、NPR-B与NF-κB信号通路在胃癌中的研究进展
Research Progress of CNP,NPR-B and NF-κB Signaling Pathway in Gastric Cancer
摘要
Abstract
The development of gastric cancer is regulated by a combination of genes and signaling pathways.As a member of the natriuretic peptide family,C-type natriuretic peptide plays a variety of biological roles by activating cGMP through binding to its specific receptor NPR-B,which in turn regulates downstream signaling molecules.Atrial natriuretic peptide plays an anti-proliferative role and inhibits tumor migration and metastasis in gastric cancer,while C-type natriuretic peptide is structurally similar to atrial natriuretic peptide and its effector molecules are also similar,so it is presumed that C-type natriuretic peptide also has similar effects in gastric cancer.In addition,C-type natriuretic peptide can inhibit the activation of NF-κB signaling pathway,which can promote the development of gastric cancer and play an important role in apoptosis,proliferation,invasion and metastasis of gastric cancer.The article reviews the relationship between the C-type natriuretic peptide,NPR-B and NF-κB signaling pathway and the development of gastric cancer,aiming to provide effective reference values for scientific research and clinical treatment.关键词
CNP/NPR-B/NF-κB信号通路/胃癌Key words
CNP/NPR-B/NF-κB signaling pathway/Gastric cancer分类
医药卫生引用本文复制引用
李姗姗,刘海旺,李春辉..CNP、NPR-B与NF-κB信号通路在胃癌中的研究进展[J].医学信息,2023,36(23):165-169,5.基金项目
2018年河北省资助专科能力建设和专科带头人培养项目(编号:361008) （编号:361008）
