现代畜牧科技Issue(12)：115-118,4.DOI:10.19369/j.cnki.2095-9737.2023.12.030
细菌样颗粒-乳酸菌表面展示技术在黏膜疫苗中的应用
Application of Bacterial-like Particles-surface Display Technology of Lactic Acid Bacteria in Mucosal Vaccine
乔海英 1李梦曼 2胡念之 1谭成成 1王伟霞 1孙丽敏 1李信涛 1张鹏举1
作者信息
- 1. 吉林省农业科学院畜牧兽医研究所,吉林 长春 130000
- 2. 吉林省农业科学院科技交流合作处,吉林 长春 130000
- 折叠
摘要
Abstract
Bacteria-like particles(BLP)are nonliving spherical particles with a diameter of 1～2 μm,mainly composed of peptidoglycan(PGN)outer surface.These particles can bind to exogenous antigens by PA with high affinity and high loading capacity to form hollow surface display particles.BLP surface display system,as a safe,effective,inexpensive and multifunctional protein antigen loading platform,has been widely used in the development of mucosal adjuvant and mucosal vaccine.This article reviewed the construction,advantages and application of BLP in mucosal vaccine.关键词
细菌样颗粒/表面展示技术/疫苗Key words
bacterial-like particles/Surface display technology/vaccine分类
生物科学引用本文复制引用
乔海英,李梦曼,胡念之,谭成成,王伟霞,孙丽敏,李信涛,张鹏举..细菌样颗粒-乳酸菌表面展示技术在黏膜疫苗中的应用[J].现代畜牧科技,2023,(12):115-118,4.
