中国当代儿科杂志2023，Vol.25Issue(12)：1211-1218,8.DOI:10.7499/j.issn.1008-8830.2305067
外周血淋巴细胞亚群对静脉注射免疫球蛋白无反应型川崎病患儿的预测价值
Predictive value of peripheral blood lymphocyte subsets for children with intravenous immunoglobulin-resistant Kawasaki disease
摘要
Abstract
Objective Based on peripheral blood lymphocyte subsets and common laboratory test indexes,this study aimed to construct a predictive scoring system for intravenous immunoglobulin(IVIG)-resistant Kawasaki disease(KD).Methods Children hospitalized in Tianjin Children's Hospital from January 2021 to March 2023 were included in the study(185 cases of IVIG-sensitive KD and 41 cases of IVIG-resistant KD).Forty-six healthy children matched for age and gender were selected as controls.The relative percentage and absolute counts of peripheral lymphocyte subsets were measured by flow cytometry.Multivariate logistic regression was used to identify the predictive factors for IVIG-resistant KD and to construct a predictive scoring system for predicting IVIG-resistant KD.Results The multivariate logistic regression analysis showed that CD4+ T cell absolute count,natural killer cell absolute count,serum sodium level,globulin level,and total bilirubin level were identified as predictive factors for IVIG-resistant KD(P<0.05).The predictive scoring system based on these factors achieved a sensitivity of 70.7%and a specificity of 83.8%in predicting IVIG-resistant KD.Conclusions Peripheral blood lymphocyte subsets can serve as predictive indicators for IVIG-resistant KD in children.The introduction of this indicator and the establishment of a scoring system based on it can provide a higher accuracy in predicting IVIG-resistant KD in children.关键词
川崎病/外周血淋巴细胞亚群/静脉注射免疫球蛋白无反应/评分体系/儿童Key words
Kawasaki disease/Peripheral blood lymphocyte subsets/Resistance to intravenous immunoglobulin/Scoring system/Child引用本文复制引用
薛燕,尹晶,许俐,党利亨,王朝,崔亚琼,张新杰,李崇巍..外周血淋巴细胞亚群对静脉注射免疫球蛋白无反应型川崎病患儿的预测价值[J].中国当代儿科杂志,2023,25(12):1211-1218,8.基金项目
天津市卫生健康科技项目(ZC20066) （ZC20066）
天津市医学重点学科(专科)建设项目(TJYXZDXK-040A). （专科）
