中国当代儿科杂志2023，Vol.25Issue(12)：1219-1226,8.DOI:10.7499/j.issn.1008-8830.2306097
血小板与淋巴细胞比值对中国川崎病患儿冠状动脉病变预测价值的Meta分析
Platelet-to-lymphocyte ratio as a biomarker for predicting coronary artery lesions in Chinese children with Kawasaki disease:a Meta analysis
摘要
Abstract
Objective To systematically evaluate the value of the platelet-to-lymphocyte ratio(PLR)in predicting coronary artery lesions(CAL)in Chinese children with Kawasaki Disease(KD).Methods A comprehensive search was conducted in databases including PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang Data,China Biomedical Literature Database,and China Science and Technology Journal Database from inception to December 2022.The quality of the included literature was assessed using the Newcastle-Ottawa Scale,and a Meta analysis was performed using Stata 15.1.Results A total of ten published reports,involving 3 664 Chinese children with KD,were included in this Meta analysis,of whom 1 328 developed CAL.The Meta analysis revealed a sensitivity of 0.78(95%CI:0.71-0.83),specificity of 0.71(95%CI:0.61-0.80),overall diagnostic odds ratio of 8.69(95%CI:5.02-15.06),and an area under the curve of the summary receiver operating characteristic of 0.82(95%CI:0.78-0.85)for PLR in predicting CAL in the children with KD.The sensitivity,specificity,and area under the curve of summary receiver operating characteristic were lower for PLR alone compared to PLR in combination with other indicators.Sensitivity analysis demonstrated the stability of the Meta analysis results with no significant changes upon excluding individual studies.However,a significant publication bias was observed(P<0.001).Conclusions PLR demonstrates certain predictive value for CAL in Chinese children with KD.关键词
川崎病/血小板淋巴细胞比值/冠状动脉病变/Meta分析/儿童Key words
Kawasaki disease/Platelet-to-lymphocyte ratio/Coronary artery lesion/Meta analysis/Child引用本文复制引用
李燕羽,袁晨辰,蔡艾媛,周博举,黄腾..血小板与淋巴细胞比值对中国川崎病患儿冠状动脉病变预测价值的Meta分析[J].中国当代儿科杂志,2023,25(12):1219-1226,8.基金项目
国家中医药管理局罗笑容全国名老中医药专家传承工作室建设项目(14GG2X02). （14GG2X02）
