中国当代儿科杂志2023，Vol.25Issue(12)：1234-1238,5.DOI:10.7499/j.issn.1008-8830.2308073
川崎病基因多态性的研究进展
Research advances in genetic polymorphisms in Kawasaki disease
董明星 1王喜霞 1焦富勇 2张维华3
作者信息
- 1. 陕西中医药大学,陕西咸阳 712000
- 2. 陕西省川崎病诊疗中心/陕西省人民医院儿童病院,陕西西安 710068
- 3. 陕西中医药大学,陕西咸阳 712000||咸阳市儿童医院,陕西咸阳 712000
- 折叠
摘要
Abstract
Kawasaki disease(KD)is a systemic inflammatory vascular disorder that predominantly affects children and is the leading cause of acquired heart disease in children.Although the etiology of this disease remains unclear,genome-wide association and genome-wide linkage studies have shown that some susceptible genes and chromosomal regions are associated with the development and progression of KD.With the advancement of high-throughput DNA sequencing techniques,more and more genomic information related to KD is being discovered.Understanding the genes involved in the pathogenesis of KD may provide novel insights into the diagnosis and treatment of KD.By analyzing related articles and summarizing related research advances,this article mainly discusses the T cell activation-enhancing genes that have been confirmed to be closely associated with the development and progression of KD and reveals their association with the pathogenesis of KD and coronary artery lesions.关键词
川崎病/基因多态性/易感性/冠状动脉病变Key words
Kawasaki disease/Genetic polymorphism/Susceptibility/Coronary artery lesion引用本文复制引用
董明星,王喜霞,焦富勇,张维华..川崎病基因多态性的研究进展[J].中国当代儿科杂志,2023,25(12):1234-1238,5.
