中国当代儿科杂志2023，Vol.25Issue(12)：1259-1264,6.DOI:10.7499/j.issn.1008-8830.2307109
外周血C3aR1及NETs表达水平对脓毒症性凝血病的预测价值
Value of the expression levels of complement-3a receptor 1 and neutrophil extracellular traps in predicting sepsis-induced coagulopathy
摘要
Abstract
Objective To investigate the clinical value of complement-3a receptor 1(C3aR1)and neutrophil extracellular traps(NETs)in predicting sepsis-induced coagulopathy(SIC).Methods A prospective study was conducted among 78 children with sepsis who attended Xuzhou Children's Hospital Affiliated to Xuzhou Medical University from June 2022 to June 2023.According to the presence or absence of SIC,they were divided into two groups:SIC(n=36)and non-SIC(n=42).The two groups were compared in terms of clinical data and the levels of C3aR1 and NETs.The factors associated with the occurrence of SIC were analyzed.The receiver operating characteristic(ROC)curve was used to evaluate the performance of C3aR1 and NETs in predicting SIC.Results Compared with the non-SIC group,the SIC group had significantly higher levels of C-reactive protein,interleukin-6(IL-6),interleukin-10,C3aR1,and NETs(P<0.05).The multivaiate logistic regression analysis showed that the increases in C3aR1,NETs,and IL-6 were closely associated with the occurrence of SIC(P<0.05).The ROC curve analysis showed that C3aR1 combined with NETs had an area under the curve(AUC)of 0.913 in predicting SIC(P<0.05),which was significantly higher than the AUC of C3aR1 or IL-6(P<0.05),while there was no significant difference in AUC between C3aR1 combined with NETs and NETs alone(P>0.05).Conclusions There are significant increases in the expression levels of C3aR1 and NETs in the peripheral blood of children with SIC,and the expression levels of C3aR1 and NETs have a high clinical value in predicting SIC.关键词
脓毒症/脓毒症性凝血病/补体C3a受体1/中性粒细胞胞外诱捕网/儿童Key words
Sepsis/Sepsis-induced coagulopathy/Complement-3a receptor1/Neutrophil extracellular trap/Child引用本文复制引用
曹锐,刘开勋,胡丹,齐共健..外周血C3aR1及NETs表达水平对脓毒症性凝血病的预测价值[J].中国当代儿科杂志,2023,25(12):1259-1264,6.基金项目
徐州市科技计划项目(KC21180). （KC21180）
