中国动脉硬化杂志2023，Vol.31Issue(11)：969-974,6.DOI:10.20039/j.cnki.1007-3949.2023.11.006
急性心肌梗死患者TyG指数与冠状动脉病变严重程度的相关性
Correlation between TyG index and severity of coronary artery disease in patients with acute myocardial infarction
摘要
Abstract
Aim To investigate the correlation between triglyceride-glucose(TyG)index and the severity of cor-onary artery disease assessed in patients with acute myocardial infarction(AMI).Methods The study restrospectively selected 424 patients with AMI in the Fourth Affiliated Hospital of Xinjiang Medical University from January 2020 to March 2023.Clinical data and results of coronary angiography(CAG)were collected.Gensini score was used to quantitatively assess the degree of coronary artery stenosis.According to tertiles of the Gensini,the patients were clas-sifified into three groups:low Gensini score group(＜45 points,n=140),medium Gensini score group(45～86 points,n=143),and high Gensini score group(≥87 points,n=141).The associations between TyG index and the occurrence of coronary artery disease with high Gensini score by Logistic regression analysis;Spearman correlation was used to analyze the correlation between TyG index and Gensini score in AMI patients;ROC curve was used to analyze the value of TyG in-dex in predicting the severity of coronary artery lesions.Results TyG index of high Gensini score group was signifi-cantly higher than that of low and medium Gensini score group(P＜0.05).Logistic regression analysis showed that TyG index was an independent risk factor for severe coronary lesions in AMI patients(OR=13.327,95％CI:2.642～67.235,P=0.002).Spearman correlation analysis showed that TyG index was positively correlated with the severity of coronary artery disease(r=0.331,P＜0.001).ROC curve analysis showed that the area under curve of TyG index was 0.680(95％CI:0.630～0.731,P＜0.001).When the cut-off value of TyG index was 1.555,the predicted efficacy of of se-vere coronary artery disease in patients with AMI was the highest,with a sensitivity of 79.4％and a specificity of 50.5％.Conclusion TyG,as a novel biomarker,was significantly and independently associated with the severity of the coronary arteries in patients with AMI.关键词
TyG指数/急性心肌梗死/冠状动脉病变严重程度/Gensini评分Key words
triglyceride-glucose index/acute myocardial infarction/severity of coronary artery disease/Gensini score分类
医药卫生引用本文复制引用
陈艳丽,何雄,帕尔哈提·吐尔逊..急性心肌梗死患者TyG指数与冠状动脉病变严重程度的相关性[J].中国动脉硬化杂志,2023,31(11):969-974,6.基金项目
新疆维吾尔自治区自然科学基金面上项目(2022D01C165) （2022D01C165）
