中国临床药理学杂志2023，Vol.39Issue(23)：3347-3350,4.DOI:10.13699/j.cnki.1001-6821.2023.23.001
依达拉奉右莰醇治疗急性缺血性脑卒中患者的临床研究
Clinical trial of edaravone dexborneol in the treatment of patients with acute ischemic stroke
摘要
Abstract
Objective To observe the clinical efficacy and safety of edaravone and dexborneol concentrated solution for injection in the treatment of patients with ischemic stroke.Methods Patients with acute ischemic stroke were divided into two groups,the control group was given conventional treatment,the treatment group was given edaravone and dexborneol concentrated solution for injection 15 mL on the basis of conventional treatment.The clinical efficacy of the two groups was compared.The National Institutes of Health stroke scale(NHISS)score was used to evaluate the neurological function of the patients,the modified RanKin scale(mRS)was used to evaluate the ability of daily living of the patients,and the adverse drug reactions during the treatment was observed.Results There were 63 cases in the control group and 75 cases in the treatment group.After treatment,the total effective rates of the treatment group and the control group were 85.33％(64 cases/75 cases)and 65.07％(41 cases/63 cases),and the difference was statistically significant(P＜0.05).After treatment,the differences of NHISS score before and after treatment in the treatment group and the control group were(2.11±1.01)and(0.99±0.68)points;the differences of mRS score were(0.96±0.57)and(0.63±0.41)points,and the differences were statistically significant(P＜0.01,P＜0.05).The adverse drug reactions in the two groups were nausea and vomiting,abnormal liver and kidney function.The total incidences of adverse drug reactions in the treatment group and control group were 2.67％and 6.35％,and the difference was not statistically significant(P＞0.05).Conclusion Edaravone and dexborneol concentrated solution for injection can improve the therapeutic effect of acute ischemic stroke without increasing the incidence of adverse drug reactions.关键词
依达拉奉右莰醇注射用浓溶液/急性缺血性脑卒中/神经功能/有效性/安全性评价Key words
edaravone and dexborneol concentrated solution for injection/acute ischemic stroke/neurological function/effectiveness/safety evaluation分类
医药卫生引用本文复制引用
李文利,张甜甜,郑天伦,霍颖浩,张志清..依达拉奉右莰醇治疗急性缺血性脑卒中患者的临床研究[J].中国临床药理学杂志,2023,39(23):3347-3350,4.基金项目
中国医药卫生事业发展基金资助项目 （）
