摘要
Abstract
Objective To observe the effects of Xingnaojing injection on endoplasmic reticulum stress,cerebral edema degree and neurological function in patients with traumatic intracerebral hemorrhage.Methods Patients with traumatic intracerebral hemorrhage were randomly divided into treatment group and control group according to the random number table method.The control group received conventional treatment for traumatic intracerebral hemorrhage,and the treatment group was intravenously given Xingnaojing injection 20 mL,once a day on the basis of the control group.Both groups of patients were treated continuously for 14 d.The clinical efficacy and endoplasmic reticulum stress indicators,cerebral edema degree and neurological function before and after treatment were compared between the two groups of patients,and the adverse drug reactions were analyzed.The prognosis was evaluated at 6 months after treatment.Results Two cases were shed during treatment,thus 52 cases in treatment group and 50 cases in control group were finally included.After treatment,the total effective rate in treatment group and control group were 92.31％(48 cases/52 cases)and 78.00％(39 cases/50 cases),with significant difference(P＜0.05).After treatment,serum glucose-regulatory protein 78(GRP78)in treatment group and control group were(10.42±2.14)and(14.49±2.62)μg·L-1;CCAAT/enhancer binding protein(CHOP)were(821.38±186.43)and(992.46±216.18)μg·L-1;caspase-12 were(82.42±15.17)and(96.08±20.01)pmol·L-1;hematoma volume were(6.48±2.68)and(9.14±3.13)mL;edema volume were(2.76±0.82)and(3.59±0.87)mL;National Institutes of Health Stroke Scale(NIHSS)score were 6.72±2.08 and 8.84±2.21;the European Stroke Scale(ESS)were 65.31±8.43 and 61.69±7.92,the differences were all statistically significant(all P＜0.05).The incidence of adverse drug reactions in treatment group and control group were 15.38％(10 cases/52 cases)and 8.00％(4 cases/50 cases),with no statistical significance(P＞0.05).Six months after treatment,the recovery rate of treatment group and control group were 69.23％(36 cases/52 cases)and 50.00％(25 cases/50 cases),the difference was statistically significant(P＜0.05).Conclusion Xingnaojing injection has good clinical efficacy and safety in the treatment of patients with traumatic intracerebral hemorrhage.It can improve the endoplasmic reticulum stress level,relieve the degree of cerebral edema,further promote the recovery of neurological function,and improve the prognosis of patients.关键词
醒脑静注射液/创伤性脑出血/内质网应激/脑水肿/神经功能Key words
Xingnaojing injection/traumatic intracerebral hemorrhage/endoplasmic reticulum stress/cerebral edema/neurological function分类
医药卫生
