摘要
Abstract
Objective To explore the analgesic effect of dezocine in patients with gallbladder polyps after laparoscopic cholecystectomy(LC).Methods Patients with gallbladder polyps undergoing LC were enrolled.According to postoperative analgesics,they were divided into control group(sufentanil)and treatment group(dezocine combined with sufentanil).The scores of visual analogue scale(VAS)and Ramsay sedation scale(RSS),mean arterial pressure(MAP),heart rate(HR),stress hormones[cortisol(Cor),catecholamine(CA),norepinephrine(NE)]and the occurrence of adverse reactions were compared between the two groups.Results There were 47 subjects in the control group and 55 subjects in the treatment group.The MAP values at T1-T3 in the treatment group were(90.95±16.23),(93.27±10.95),and(89.80±13.18)mmHg,which were significantly lower than those in the control group[(110.60±15.51),(103.26±12.85),and(104.28±13.09)mmHg](all P＜0.05).The HR values at T1-T3 in the treatment group were(72.69±6.73),(75.69±6.73),and(70.67±7.62)beats·min-1,which were significantly lower than those in the control group[(86.32±12.01),(81.47±9.93),and(81.40±8.14)beats·min-1](all P＜0.05).The VAS scores at T5 and T6 in the treatment group were 3(2,3)and 2(2,3),significantly lower than those in the control group[3(3,4)and 3(3,3)](all P＜0.05).The RSS score at T5 in the treatment group was 2(2,2),significantly higher than that in the control group[2(1,2)](P＜0.05).The Cor levels at T4 and T5 in the treatment group were(279.04±31.42)and(308.78±41.73)nmol·L-1,significantly lower than those in the control group[(326.29±38.51)and(356.94±43.76)nmol·L-1](all P＜0.05).The CA levels at T4 and T5 in the treatment group were(232.85±31.99)and(241.50±30.11)pg·mL-1,significantly lower than those in the control group[(263.18±37.51)and(291.25±33.27)pg·mL-1](all P＜0.05).The NE levels at T4 and T5 in the treatment group were(163.21±25.97)and(192.26±28.69)ng·L-1,significantly lower than those in the control group[(194.99±22.66)and(213.74±32.27)ng·L-1](all P＜0.05).The adverse drug reactions that occurred in the control group mainly included sedation,nausea,vomiting,and respiratory suppression,with incidence rate of 19.15％.The adverse drug reactions that occurred in the treatment group mainly included sedation and nausea,with incidence rate of 5.45％.The incidence rate of adverse drug reactions in the treatment group was significantly lower than that in the control group(P＜0.05).Conclusion Dezocine combined with sufentanil for postoperative analgesia can significantly relieve pain,relieve stress response secondary to postoperative pain and reduce the occurrence of anesthesia-related adverse reactions in patients with gallbladder polyps after LC.关键词
地佐辛/舒芬太尼/胆囊息肉/腹腔镜胆囊切除术/术后镇痛/应激反应Key words
dezocine/sufentanil/gallbladder polyp/laparoscopic cholecystectomy/postoperative analgesia/stress response分类
医药卫生
