中国临床药理学杂志2023，Vol.39Issue(23)：3499-3503,5.DOI:10.13699/j.cnki.1001-6821.2023.23.034
特发性肺纤维化中上皮-间质转化的研究现状
Research status of epithelial-mesenchymal transition in idiopathic pulmonary fibrosis
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a refractory disease,which seriously endangers the health of patients and increases the mortality of patients.Its pathogenesis is still unclear,but it is mainly driven by alveolar epithelial cell injury.Epithelial-mesenchymal transition is an important part of the disease and is considered to be a potential therapeutic target.A series of in vitro and in vivo experiments have confirmed the role in IPF.This article reviews the interaction mechanisms of IPF-related cells and fibrosis factors in IPF,in order to provide a theoretical basis for further exploration of the occurrence and development mechanism of IPF and future clinical prevention and treatment.关键词
特发性肺纤维化/肺泡上皮细胞/成纤维细胞/肌成纤维细胞/巨噬细胞/上皮-间质转化/肺纤维化因子Key words
idiopathic pulmonary fibrosis/alveolar epithelial cell/fibroblasts/myofibroblasts/macrophages cell/epithelial-mesenchymal transition/fibrosis factor分类
医药卫生引用本文复制引用
吴亚娜,刘东玲,宋忠阳,黄达,朱鹏,徐倩,张志明..特发性肺纤维化中上皮-间质转化的研究现状[J].中国临床药理学杂志,2023,39(23):3499-3503,5.基金项目
甘肃省科技重大专项基金资助项目(22ZD1FA001) （22ZD1FA001）
高端人才承担省级科技计划资助项目("长江学者奖励计划"特聘教授)(甘科计[2021]20号-9) （"长江学者奖励计划"特聘教授）
兰州市人才创新创业基金资助项目(2021-RC-80) （2021-RC-80）
兰州市科技发展计划基金资助项目(2020-XG-29) （2020-XG-29）
甘肃中医药大学附属医院院内课题资助项目(gzfy-2022-08) （gzfy-2022-08）
