中国全科医学2024，Vol.27Issue(9)：1095-1101,7.DOI:10.12114/j.issn.1007-9572.2023.0586
新疆地区高尿酸血症患病现状及其与心脏代谢指数的相关性研究
Prevalence of Hyperuricemia and Its Correlation with Cardiometabolic Index in Xinjiang Region
摘要
Abstract
Background The prevalence of hyperuricemia(HUA)is increasing year by year,and fewer studies have been conducted for the Xinjiang region.Because the population in Xinjiang has special regional and dietary characteristics,regional studies are necessary.Objective To investigate the current status of HUA among people aged≥35 years in Xinjiang Uygur Autonomous Region,and explore the correlation of cardiometabolic index(CMI)with HUA among healthy population undergoing health examinations of different ethnicities and genders,so as to provide a reference basis for the development of personalized preventive measures for HUA patients in the region.Methods This was a cross-sectional study,and 9 429 medical examiners aged≥35 years who participated in health checkups at the First Affiliated Hospital of Xinjiang Medical University from October 2021 to October 2022 were selected as the study subjects and divided into the HUA group(n=527)and the non-HUA group(n=8 902)according to the combination of HUA;and the study subjects were stratified into Q1(CMI≤0.34),Q2(0.34<CMI≤0.56),Q3(0.56<CMI≤0.99)and Q4(CMI>0.99)according to the CMI.General demographic information(gender,age,ethnicity),past medical history(coronary heart disease,hypertension,diabetes mellitus,stroke),physical examination and laboratory test indices of the study subjects were collected and compared by reviewing the medical record system.A multivariate Logistic regression model was used to analyze the effect of CMI on the risk of HUA(model Ⅰ adjusted for age,gender,gender and BMI;model Ⅱ adjusted for age,gender,past history,urea nitrogen,etc.),and the correlation between CMI and HUA was analyzed bystratification according to gender(male/female)and ethnicity(Han/Uyghur/Kazak).Results There were 527(5.58%)HUA patients among 9 429 medical examiners,with an average age of(54.3±12.9)years;434(82.4%)were male and 93(17.6%)were female;402(76.3%)of them were Han nationality,82(15.5%)were Uyghurs,and 43(8.2%)were Kazakhs.In the comparison between the HUA group and non-HUA group,there was no statistically significant difference in stroke history and HDL-C levels(P>0.05);the differences in gender,age,ethnicity,history of coronary heart disease,hypertension and diabetes,diastolic blood pressure(DBP),systolic blood pressure(SBP),urea nitrogen(UN),blood uric acid(SUA),creatinine,fasting plasma glucose(FPG),triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),BMI,waist-to-height ratio(WHtR),and CMI were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that after adjusting for relevant confounders,the risk of HUA was increased when CMI was Q2,Q3,and Q4 compared to Q1(OR=1.874,4.201,6.053;P<0.05),and CMI was positively associated with the risk of HUA(Ptrend<0.001).Stratified by gender after adjusting for relevant confounders,the results showed that compared with Q1,a CMI of Q3,Q4 increased the risk of HUA in men(OR=3.168,4.273;P<0.05),and a CMI of Q2,Q3,and Q4 increased the risk of HUA in women(OR=3.144,8.805,10.938;P<0.05),and CMI was positively associated with the risk of HUA(Ptrend<0.001).The results after adjusting for relevant confounders stratified by different ethnic groups showed that compared with Q1,the risk of HUA was increased at CMIs of Q2,Q3,and Q4 in Han nationality(OR=1.924,4.522,6.681;P<0.05),and at CMIs of Q2,Q3,and Q4 in Kazakhs(OR=4.004,9.461,14.291;P<0.05),and CMI was positively associated with the risk of HUA development in all cases(Ptrend<0.001).Conclusion The prevalence of HUA among medical examiners aged≥35 years in Xinjiang Uygur Autonomous Region was 5.58%,and HUA patients were predominantly male and Han nationality.Elevated CMI increases the risk of HUA,which is more pronounced in Han and Kazakh populations.关键词
高尿酸血症/心脏代谢指数/新疆维吾尔自治区/哈萨克族/横断面研究/Logistic模型Key words
Hyperuricemia/Cardiometabolic index/Xinjiang/Kazak nationality/Cross-sectional studies/Logistic models分类
医药卫生引用本文复制引用
李幸,杨毅宁..新疆地区高尿酸血症患病现状及其与心脏代谢指数的相关性研究[J].中国全科医学,2024,27(9):1095-1101,7.基金项目
新疆维吾尔自治区重点研发计划(202007035,2020B03002-2) （202007035,2020B03002-2）
