中国输血杂志2023，Vol.36Issue(11)：1008-1011,4.DOI:10.13303/j.cjbt.issn.1004-549x.2023.11.008
低剂量单采血小板预防性输注在血液病中的疗效分析
Efficacy of low dose apheresis platelet prophylactic infusion in hematological diseases:a retrospective study
胡燕 1漆宇 1吴雅娟 1黎欢 1张利 1徐弘 1彭涛 1甘新宇1
作者信息
- 1. 西部战区总医院 输血医学科,四川 成都 610036
- 折叠
摘要
Abstract
Objective To retrospectively analyze the efficacy of low dose apheresis platelet prophylactic infusion and ex-plore its feasibility.Methods A total of 392 inpatients with platelet transfusion in our hospital from November 2020 to Sep-tember 2021 were selected.The conventional dose(1 therapeutic dose)of apheresis platelet transfusion was set as the control group,and the low dose(0.5 therapeutic dose)as the experimental group.Platelet count before and after infusion,platelet elevation value(△PLT)and 24 h platelet count correction increase index(CCI)were observed,and the efficacy of low-dose platelet infusion was analyzed by disease type and gender.Results The △PLT value and 24h CCI effective infusion rate in control group were higher than those in experimental group:(16±16)×109vs(7±10)×109,71.94% vs 60.46%,P＜0.05.The △PLT value of the control group was about 1.2-3.5 times that of the experimental group,and the effective rate was about 1-1.4 times.In control group,the△PLT(×109)was AML(20±14)＞AA(14±14)＞ALL(13±12)＞NHL(9±8)＞MDS(7±6).In the experimental group,the △PLT(×109)was AA(11±18)＞AML(8±8)＞ALL(5±7)＞NHL(5±7)＞MDS(6±16).The 24h CCI was AML(163/188,86.70%)＞AA(23/32,71.88%)＞ALL(65/98,66.33%)＞MDS(9/17,52.94%)＞NHL(12/22,51.55%)in the control group,and AML(133/188,70.74%)＞AA(19/32,59.38%)＞NHL(12/22,51.55%)＞ALL(47/98,47.96%)＞MDS(8/17,47.06%)in the experimental group.The effective infusion rates of AML and ALL2 in the experimental groups were 70.74%(133/188)and 47.96%(47/98),respectively,significantly lower than 86.7%(163/188)and 66.33%(65/98)in the control group(P＜0.05).No significant difference was noticed in the ef-fective infusion rate between the experimental group and the control group for other diseases(P＞0.05).Conclusion Low-dose apheresis platelet prophylactic infusion can alleviate the between supply shortage,with an effective infusion rate of 60.46%(236/392),which has certain clinical application value.Patients with AML,AA or ALL were recommended with low dose platelets,while patients with MDS and NHL were not recommended.关键词
血小板输注/血小板剂量/疗效/血液病Key words
platelet transfusion/platelet dose/efficacy/hematological disease分类
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胡燕,漆宇,吴雅娟,黎欢,张利,徐弘,彭涛,甘新宇..低剂量单采血小板预防性输注在血液病中的疗效分析[J].中国输血杂志,2023,36(11):1008-1011,4.
