中国兽医科学2023，Vol.53Issue(12)：1475-1479,5.DOI:10.16656/j.issn.1673-4696.2023.0208
硫酸乙酰肝素的组成及其对病毒感染的影响
The structure of heparan sulfate and its effect on viral infection
摘要
Abstract
Heparan sulfate(HS)is a linear sulfated isomeric polysaccharide composed of multiple disaccharide repeat units,which is widely found in mammalian cell surface and extracellular matrix.HS molecules could recognize and bind to positively charged virion,finally enhancing viral infectivity to host cells.Therefore,HS is identified as a specific receptor for virus to invade host cells.It has been reported that HS plays critical roles in viral invasion by participating in the adsorption and en-try process of many viruses,such as Foot-and-mouth disease virus(FMDV).In this review,the composi-tions of HS and its influence on virus infection are summarized in order to provide references for HS research.关键词
硫酸乙酰肝素/受体/病毒感染Key words
heparan sulfate/receptor/viral infection分类
农业科技引用本文复制引用
黄磊,李冬,陈应理,刘在新,卢曾军,白兴文,袁红,宫晓华,包慧芳,王利豪,王涛,高洁,李平花,孙普..硫酸乙酰肝素的组成及其对病毒感染的影响[J].中国兽医科学,2023,53(12):1475-1479,5.基金项目
国家重点研发计划项目(2021YFD1800300) （2021YFD1800300）
国家自然科学基金面上项目(31772763) （31772763）
甘肃省重大科技专项(21ZD3NA001,22ZD6NA012,22ZD6NA001) （21ZD3NA001,22ZD6NA012,22ZD6NA001）
国家生猪技术创新中心项目(NCTIP-XD/C03) （NCTIP-XD/C03）
