中国现代医生2023，Vol.61Issue(34)：14-18,5.DOI:10.3969/j.issn.1673-9701.2023.34.004
肺癌化疗患者发生肺部感染危险因素的Meta分析
Risk factors for pulmonary infection in patients with lung cancer after chemotherapy:A Meta-analysis
摘要
Abstract
Objective To systematically evaluate the risk factors for pulmonary infection in patients with lung cancer after chemotherapy.Methods CNKI,Wanfang Data,VIP,PubMed,Embase,and the Cochrane Library were searched from inception to October 2022 to collect case-control studies and cohort studies about risk factors for pulmonary infection in patients with lung cancer after chemotherapy.Two researchers independently conducted literature screening,data extraction,and quality assessment.Rev Man 5.3 software was used for Meta-analysis.Results A total of 15 literatures were included,including 3960 patients with lung cancer after chemotherapy.Meta analysis results showed that age≥60 years,smoking history,drinking history,hypertension,diabetes mellitus,atelectasis,hypoproteinaemia,TNM staging of stage Ⅲ-Ⅳ,central lung cancer,small cell lung cancer,invasive operation,Karnofsky performance status score＜80 points before chemotherapy,combined chemotherapy drugs,duration of chemotherapeutic ˃2 weeks,white blood cell count≤3.0×109/L after chemotherapy,albumin＜30g/L after chemotherapy,and hospital stay>20 days were risk factors for pulmonary infection in patients with lung cancer after chemotherapy(P＜0.05).Conclusion There were many risk factors for pulmonary infection in patients with lung cancer after chemotherapy.Prevention and control measures should be taken based on the related risk factors to reduce the incidence rate of pulmonary infection.关键词
肺癌/化疗/肺部感染/危险因素/Meta分析Key words
Lung cancer/Chemotherapy/Pulmonary infection/Risk factor/Meta analysis分类
医药卫生引用本文复制引用
谢双燕,李思瑾,李泽云,马阿敏,余咏兰,谢独..肺癌化疗患者发生肺部感染危险因素的Meta分析[J].中国现代医生,2023,61(34):14-18,5.基金项目
广东省中医药局科研项目(20211139) （20211139）
广州中医药大学第一附属医院创新强院青年基金项目(2019QN09) （2019QN09）
