中国现代医生2023，Vol.61Issue(34)：31-33,80,4.DOI:10.3969/j.issn.1673-9701.2023.34.008
注射式自体组织匀浆移植术在继发性甲状旁腺功能亢进症手术治疗中的应用研究
Application of injection autologous tissue homogenate implantation in surgical treatment of secondary hyperparathyroidism
摘要
Abstract
Objective To investigate the application value of injectable autogenous tissue homogenate implantation in surgical treatment of secondary hyperparathyroidism(SHPT).Methods A total of 46 patients with SHPT who underwent long-term regular hemodialysis and failed medical treatment in Sichuan Mianyang 404 Hospital from June 2017 to June 2021 were selected.According to random number table method,the patients were divided into homogenate injection group and particle embedding group,with 23 cases in each group.Parathyroidectomy(PTX)plus autogenous forearm injection homogenate implantation was performed in homogenate injection group,and PTX plus autogenous forearm particle implantation was performed in particle embedding group.The changes in blood calcium,blood phosphorus,intact parathyroid hormone(iPTH),and alkaline phosphatase(ALP)of two groups before and after operation,as well as the improvements in vascular calcification,pruritus,bone pain,and sleep disorders after operation were compared.Results One year after surgery,the serum calcium level of two groups were significantly higher than before treatment,and the serum phosphorus,iPTH and ALP levels were significantly lower than before treatment(P<0.05).The serum calcium level in homogenate injection group was significantly higher than that in particle embedding group,and the serum phosphorus,iPTH and ALP levels were significantly lower than those in particle embedding group(P<0.05).The improvement of blood vessel calcification,pruritus,bone pain and sleep disorder in homogenate injection group were better than those in particle embedding group(P<0.05).Conclusion Injectable autologous tissue homogenate implantation for refractory SHPT patients is safe and effective,with high success rate,less trauma,and can improve patient symptoms and quality of life.关键词
甲状旁腺切除术/匀浆注射/移植/甲状旁腺功能亢进症Key words
Parathyroidectomy/Homogenate injection/Implantation/Hyperparathyroidism分类
医药卫生引用本文复制引用
肖胜,邓菲,谢田伟,杨霜,简讯..注射式自体组织匀浆移植术在继发性甲状旁腺功能亢进症手术治疗中的应用研究[J].中国现代医生,2023,61(34):31-33,80,4.基金项目
四川省绵阳市卫生健康委员会科研课题(201958) （201958）
