摘要
Abstract
Objective To analyze the relationship between cognitive and psychiatric symptoms and serum folate,homocysteine(Hcy)and vitamin B12 in patients with Alzheimer's disease(AD).Methods Fifty-eight patients with AD who were treated in Hangzhou Seventh People's Hospital from March 2019 to April 2022 were retrospectively selected.According to the score of neuropsychiatric inventory questionnaire(NPI-Q),they were divided into observation group A(NPI-Q<14 points,36 cases)and observation group B(NPI-Q≥14 points,22 cases).Fifty-eight elderly persons who underwent physical examination during the same period were included in control group.The general data,serum folate,Hcy,vitamin B12 levels,mini-mental state examination(MMSE)score,NPI-Q score,clinical dementia rating(CDR)score were compared among the three groups.Results There was statistical significance in age comparison among the three groups(P<0.05),that is control group<observation group A<observation group B.There was no significant difference in other general information among the three groups(P>0.05).There were significant differences in MMSE,NPI-Q,CDR scores and serum folate,Hcy and vitamin B12 levels among the three groups(P<0.05).After controlling for variables,MMSE score was positively correlated with folate and negatively correlated with Hcy;NPI-Q score was negatively correlated with folate and vitamin B12,and positively correlated with Hcy;CDR score was negatively correlated with folate and vitamin B12,and positively correlated with Hcy(P<0.05).Serum Hcy levels in AD patients with emotional symptoms or psychiatric symptoms or impaired frontal lobe function were significantly higher than those in asymptomatic AD patients(P<0.05).Conclusion Detection of serum folate,Hcy,vitamin B12 levels is beneficial to the diagnosis of AD patients.关键词
阿尔茨海默病/认知功能/精神症状/叶酸/同型半胱氨酸/维生素B12Key words
Alzheimer's disease/Cognitive function/Psychiatric symptom/Folate/Homocysteine/Vitamin B12分类
医药卫生
