中医药学报2023，Vol.51Issue(12)：113-122,10.DOI:10.19664/j.cnki.1002-2392.230266
三七中的化学成分在不同抑郁症模型中的作用和机制研究进展
Research Progress on the Role and Mechanism of Chemical Components in Panax Notoginseng in Different Depression Models
摘要
Abstract
Depression is a common mental disorder,which is highly disabling and fatal.Western medicine usually uses oral antidepressants for treatment,but their long treatment cycle,obvious side effects,high price,poor compliance,limited response rate,and delayed efficacy limit their application.More and more studies have revealed that traditional Chinese medicine has outstanding therapeutic effects in the treatment of depression and can serve as a prospective alternative therapy for depression.Panax notoginseng is a traditional Chinese medicinal herb in China.Modern research has found that it has pharmacological effects such as inhibiting neuronal apoptosis,inhibiting platelet aggregation,antioxidant,anti-inflammatory,and neuronal protection.In recent years,a large amount of experimental data has been generated on the therapeutic effects and pharmacological studies of Panax notoginseng on various depression models.However,the potential impact and mechanism of Panax notoginseng and its chemical components on depression have not been fully determined.Therefore,this paper reviews the antidepressant mechanisms of the main chemical components in Panax notoginseng in different depression models,providing a theoretical basis for clarifying the antidepressant mechanism of Panax notoginseng and promoting the development of new traditional Chinese medicine therapies and drugs for depression.关键词
抑郁症/替代疗法/三七/化学成分/抗抑郁机制Key words
Depression/Alternative therapy/Panax notoginseng/Chemical composition/Antidepressant mechanism分类
医药卫生引用本文复制引用
薛剑,王宇,刘树民..三七中的化学成分在不同抑郁症模型中的作用和机制研究进展[J].中医药学报,2023,51(12):113-122,10.基金项目
黑龙江省自然科学基金项目(LH2022H069) （LH2022H069）
黑龙江中医药大学科研基金项目(2019MS09) （2019MS09）
黑龙江省中医药科研项目(ZHY16-092) （ZHY16-092）
