安徽中医药大学学报2023，Vol.42Issue(6)：28-32,5.DOI:10.3969/j.issn.2095-7246.2023.06.007
吴门解毒通络外治法对克罗恩病肛瘘手术后创面和炎症因子的影响
Effect of Wumen Detoxicating and Collateral-dredging External Treatment on Trauma and Inflammatory Factors after Anal Fistula Surgery for Crohn's Disease
摘要
Abstract
Objective To investigate the effect of Wumen detoxicating and collateral-dredging external treatment on trauma and inflammatory factors after anal fistula surgery for Crohn's disease.Methods A total of 60 patients with Crohn's disease and a-nal fistula were randomly divided into control group and observation group,with 30 patients in each group.The patients in the control group were given infliximab combined with thread-drawing draisnage surgery,and those in the observation group were given fumigation-washing sitz bath with the detoxicating and collateral-dredging prescription and enema with Huangkui Lian-chang Decoction;the course of treatment was 14 weeks for both groups.The two groups were observed in terms of wound heal-ing(wound secretion score,stitch removal time,and fistula healing time)and changes in the levels of mucosal inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-12(IL-12),and interleukin-23(IL-23)]in fistula and fistula orifice,and clinical outcome was compared between the two groups.Results After treatment,both groups had a sig-nificant reduction in wound secretion score(P＜0.05),and the observation group had a significantly greater reduction than the control group(P＜0.05);compared with the control group,the observation group had significantly shorter stitch removal time and fistula healing time(P＜0.05).After treatment,both groups had significant reductions in the levels of TNF-α,IL-6,IL-12,and IL-23(P＜0.05),and the observation group had significantly greater reductions than the control group(P＜0.05).The observation group had a significantly better clinical outcome than the control group(P＜0.05).Conclusion Detoxicating and collateral-dredging external treatment in addition to infliximab combined with thread-drawing drainage surgery can promote postoperative wound healing in patients with Crohn's disease and anal fistula,possibly by reducing the levels of inflammatory factors in fistula.关键词
克罗恩病/瘘管/炎症因子/创面愈合Key words
Crohn's disease/Fistula/Inflammatory factors/Wound healing分类
医药卫生引用本文复制引用
张莉,孙薛亮,韩娟,张兆征,文科..吴门解毒通络外治法对克罗恩病肛瘘手术后创面和炎症因子的影响[J].安徽中医药大学学报,2023,42(6):28-32,5.基金项目
苏州市科技发展计划(民生科技)项目(SS202085) （民生科技）
姑苏卫生人才培养项目(GSWS2020084) （GSWS2020084）
苏州市科技发展计划(医疗卫生科技创新-医学创新应用研究[第三批])指导性项目(SKYXD2022044) （医疗卫生科技创新-医学创新应用研究[第三批]）
