北京生物医学工程2023，Vol.42Issue(6)：566-573,8.DOI:10.3969/j.issn.1002-3208.2023.06.003
顿挫期圆锥角膜拟锥体参数与角膜动力学响应参数的关系
The relationship between corneal cone parameters and dynamic corneal response parameters in forme fruste keratoconus
摘要
Abstract
Objective The study aims to explore the influence of the position and mechanical properties of the cone of keratoconus on the dynamic corneal response (DCR) parameters. Methods Ninety patients (90 eyes) with forme fruste keratoconus (FFKC) were included. Based on the morphological data of FFKC，the cone parameters were determined by the cone automatic acquisition method. According to the cone center，21 cases in horizontal group and 20 cases in underside group were selected to analyze the difference of dynamic corneal response parameters. A finite element model of keratoconus with three different cone positions was constructed based on the geometric data of healthy eyeballs. By changing the mechanical parameters of the cone region，the simulation results of corneal dynamic response parameters under air pulse were calculated to study the relationship of the position and mechanical parameters of the corneal cone region with the DCR parameters. Results There were statistical differences among the corneal radius at time of corneal concavity (radius)， maximum inverse radius(MIR) and integrated radius (IR) due to the different positions of the cone center in forme fruste keratoconus. When the cone center was located in the paracorneal central area，only the corneal thickness of the area symmetrical to the cone center was statistically different. The finite element simulation results showed that the maximum displacement change at the corneal apex was the greatest when the cone region was located at the center of the cornea. When the cone was located on the center and the vertical line，MIR became smaller and IR became larger，and the changes of MIR and IR increased with the decrease of mechanical parameters in the cone region. When the cone region was located on the horizontal line，MIR and IR changed little. Conclusions The position and mechanical properties of cone have significant effects on DCR parameters (MIR，IR，etc.) of FFKC.关键词
顿挫期圆锥角膜/生物力学/有限元模拟/最大压陷曲率半径/积分半径Key words
forme fruste keratoconus/biomechanics/finite element simulation/maximum indentation radius of curvature/integrated radius分类
医药卫生引用本文复制引用
王维,张慧,田磊,李林,张海霞..顿挫期圆锥角膜拟锥体参数与角膜动力学响应参数的关系[J].北京生物医学工程,2023,42(6):566-573,8.基金项目
国家自然科学基金(32171304)资助 （32171304）
