川北医学院学报2023，Vol.38Issue(12)：1608-1611,4.DOI:10.3969/j.issn.1005-3697.2023.12.005
卵巢癌患者外周血T淋巴细胞与血清肿瘤标志物的相关性
Correlation between peripheral blood T lymphocytes and serum tumor markers in patients with ovarian cancer
摘要
Abstract
Objective:To study the correlation between peripheral blood T lymphocytes and serum tumor markers in patients with ovarian cancer.Methods:86 patients with ovarian cancer were selected as the malignant group,and 112 patients with ovarian be-nign tumor were selected as the benign group during the same period.The levels of peripheral blood T lymphocytes(CD3+,CD4+,CD8+ and CD4+/CD8+),serumtumor markers[soluble mesothelin-related peptide(SMRP),human epididymal protein4(HE4),carbohydrate antigen 125(CA125)]of patients in the two groups were recorded.The levels of peripheral blood T lymphocytes and ser-um tumor markers in ovarian cancer patients with different clinicopathological characteristics were compared,and Pearson correlation was used to analyze the correlation between peripheral blood T lymphocytes and serum tumor markers in ovarian cancer patients.Re-sults:The levels of peripheral blood CD3+,CD4+ and CD4+/CD8+ in the malignant group were lower than those in the benign group,and the levels of peripheral blood CD8+,serum soluble mesothelin-related peptide(SMRP),human epididymal protein 4(HE4)and carbohydrate antigen 125(CA125)in the malignant group were higher than those in the benign group(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in peripheral blood of ovarian cancer patients with clinical stage Ⅲ～Ⅳ,medium/low differentiation and lymph node metastasis were lower than those of patients with clinical stageⅠ～Ⅱ,high differentiation and no lymph node metasta-sis.The levels of peripheral blood CD8+ and serum SMRP,HE4 and CA125 were higher than those of patients with clinical stageⅠ～Ⅱ,high differentiation and no lymph node metastasis(P<0.05).Pearson correlation analysis showed that,the levels of peripheral blood CD3+,CD4+ and CD4+/CD8+ in ovarian cancer patients were negatively correlated with the levels of serum SMRP,HE4 and CA125,the level of peripheral blood CD8+ were positively correlated with serum SMRP,HE4 and CA125 levels(P<0.05).Conclusion:The levels of peripheral blood T lymphocytes and serum tumor markers in ovarian cancer patients were closely related to the occurrence and development of the disease,and there was a significant correlation between them.关键词
卵巢癌/T淋巴细胞/肿瘤标志物/良性肿瘤/相关性Key words
Ovarian cancer/T lymphocytes/Tumor markers/Benign tumor/Correlation分类
医药卫生引用本文复制引用
徐华,王丽,卢秀荣..卵巢癌患者外周血T淋巴细胞与血清肿瘤标志物的相关性[J].川北医学院学报,2023,38(12):1608-1611,4.基金项目
河北省卫健委2022年计划项目(20221897) （20221897）
