川北医学院学报2023，Vol.38Issue(12)：1629-1633,5.DOI:10.3969/j.issn.1005-3697.2023.12.010
尿毒清颗粒联合维持性血液透析对慢性肾衰竭患者肾功能及血清泌乳素、CYFRA21-1的影响
Effect of Niaoduqing Granules combined with maintenance hemodialysis on kidney function and serum prolactin and CYFRA21-1 in patients with chronic renal failure
摘要
Abstract
Objective:To investigate the effect of Niaoduqing Granules combined with maintenance hemodialysis on kidney func-tion and serum prolactin(PRL)and cytokeratin 19 fragment(CYFRA21-1)in patients with chronic renal failure(CRF).Methods:104 patients with CRF were divided according to different treatment methods.52 patients treated with maintenance hemodialysis were in-cluded in the control group,and the other 52 patients treated with Niaoduqing Granules combined with maintenance hemodialysis were included in the treatment group.All patients were treated for 6 months.The clinical efficacy,kidney function[blood urea nitrogen(BUN),serum creatinine(Scr)and creatinine clearance(Ccr)],24 h urine volume,calcium-phosphorus metabolism(blood calcium and blood phosphorus),inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)],PRL,CYFRA21-1,serum T lymphocyte subsets(CD4+,CD8+ and CD4+/CD8+),and the incidence of adverse reactions were compared between the two groups.Results:There were no significant differences in BUN,Scr,Ccr,24 h urine volume,blood calcium,blood phosphorus,TNF-α,CRP,IL-6,PRL,CYFRA21-1,CD4+,CD8+ and CD4+/CD8+ levels between the two groups before dialysis(P>0.05).After treatment,the total effective rate in the treatment group was higher than that in the control group(P<0.05).Com-pared with pre-dialysis,BUN,Scr,24 h urine volume,TNF-α,CRP,IL-6,PRL,CYFRA21-1 and CD8+ in the two groups decreased(P<0.05),and the treatment group was lower than the control group(P<0.05).Ccr,CD4+ and CD4+/CD8+ increased(P<0.05),and the treatment group was higher than the control group(P<0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group(P<0.05).There was no significant difference in blood phosphorus or blood calcium be-tween the two groups(P>0.05).Conclusion:Niaoduqing Granules combined with maintenance hemodialysis can improve kidney function in patients with CRF,reduce inflammatory factors and serum PRL and CYFRA21-1 levels,and improve immune function,with high safety.关键词
慢性肾衰竭/尿毒清颗粒/维持性血液透析/肾功能/泌乳素/细胞角蛋白19片段Key words
Chronic renal failure/Niaoduqing Granules/Maintenance hemodialysis/Kidney function/Prolactin/Cytokeratin 19 fragment分类
医药卫生引用本文复制引用
虞丽利,朱世瑶,廖洁,何信英,石运莹..尿毒清颗粒联合维持性血液透析对慢性肾衰竭患者肾功能及血清泌乳素、CYFRA21-1的影响[J].川北医学院学报,2023,38(12):1629-1633,5.基金项目
四川省科技计划项目(2022YFS0266) （2022YFS0266）
