川北医学院学报2023，Vol.38Issue(12)：1634-1638,5.DOI:10.3969/j.issn.1005-3697.2023.12.011
奥扎格雷钠联合阿司匹林治疗急性脑梗死患者疗效及对其脑血管储备能力和凝血功能的影响
Curative effect of ozagrel sodium combined with aspirin on patients with acute cerebral infarction and its influences on cerebrovascular reserve ca-pacity and coagulation function
摘要
Abstract
Objective:To study the curative effect of ozagrel sodium combined with aspirin on patients with acute cerebral infarc-tion(ACI)and its influences on cerebrovascular reserve(CVR)capacity and coagulation function.Methods:120 patients with ACI who received treatment were selected as the research objects and divided into aspirin group(aspirin enteric-coated tablets)and com-bined medication group(ozagrel sodium combined with aspirin enteric-coated tablets),with 60 cases in each group.The clinical cura-tive effect,CVR capacity,coagulation function,platelet indexes and nerve injury were compared between the two groups.Results:After treatment,clinical curative effect in combined medication group was higher than that in aspirin group(96.67%vs.81.67%,P<0.05).Middle cerebralartery(MCV)andcerebrovascularreserve(CVR)incombinedmedicationgroupwerehigherthanthoseinas-pirin group(P<0.05),while perfusion index(PI)was lower than that in aspirin group(P<0.05).Prothrombin time(PT)and acti-vated partial thromboplastin time(APTT)in combined medication group were longer than those in aspirin group(P<0.05),while Plasma fibrinogen(FIB)was lower than that in aspirin group(P<0.05).6-keto prosta-glandin F1a(6-K-PGF1a)level in combined medication group was higher than that in aspirin group(P<0.05),while levels of thromboxane B2(TXB2)and carotid artery intima-media thickness(IMT)were lower than those in aspirin group(P<0.05).NIHSS scores in combined medication group was lower than that in aspirin group(P<0.05).Conclusion:The clinical curative effect of ozagrel sodium combined with aspirin is good,which can maintain CVR capacity,reduce hypercoagulable state,promote local blood circulation and alleviate cerebral nerve injury.关键词
急性脑梗死/奥扎格雷钠/阿司匹林/脑血管储备能力/凝血功能Key words
Acute cerebral infarction/Ozagrel sodium/Aspirin/Cerebrovascular reserve capacity/Coagulation function分类
医药卫生引用本文复制引用
王晓辉,崔小丽,常莎,马妮,李志伟,王乐..奥扎格雷钠联合阿司匹林治疗急性脑梗死患者疗效及对其脑血管储备能力和凝血功能的影响[J].川北医学院学报,2023,38(12):1634-1638,5.基金项目
陕西省自然科学基础研究计划项目(2021JQ-903) （2021JQ-903）
