川北医学院学报2023，Vol.38Issue(12)：1639-1642,4.DOI:10.3969/j.issn.1005-3697.2023.12.012
司美格鲁肽对2型糖尿病合并多囊卵巢综合征患者血清超敏C反应蛋白及Ⅳ型胶原蛋白的影响
Effects of semaglutide on serum hypersensitive C-reactive protein and type Ⅳ collagen in patients with type 2 diabetes mellitus complicated with poly-cystic ovary syndrome
摘要
Abstract
Objective:To investigate the effects of semaglutide on serum hypersensitive C-reactive protein(hs-CRP)and type Ⅳ collagen(Col Ⅳ)in patients with type 2 diabetes mellitus(T2DM)complicated with polycystic ovary syndrome(PCOS).Meth-ods:30 newly diagnosed T2DM patients with PCOS were selected and treated with semaglutide for 16 weeks.The changes of indexes re-lated to blood glucose,blood lipids,body weight,sex hormone,hs-CRP and Col Ⅳ before and after treatment were analyzed and com-pared.The correlation between hs-CRP and various indexes after treatment with semaglutide were analyzed.Results:After 16 weeks of treatment,fasting blood glucose(FBG),2-hour blood glucose(2hBG),glycosylated hemoglobin A1c(HbA1C),fasting insulin(FINS),insulin resistance index(HOMA-IR),waist circumference(WC),body mass index(BMI),total triglyceride(TG),total cho-lesterol(TC),luteinizing hormone(LH),LH/FSH,total testosterone(TT),hs-CRP and Col Ⅳ were lower than those of before treat-ment,and follicle stimulating hormone(FSH)was higher than that of before treatment,the differences were statistically significant(P<0.05).Hs-CRP was positively correlated with BMI,WBC,HbA1c,FBG,2hBG,FINS,TG and Col Ⅳ after semaglutide treatment(P<0.05).Conclusion:Semaglutide can not only significantly improve blood glucose,blood lipids,body weight,insulin resistance and sex hormones in T2DM patients with PCOS,but also improve the body's inflammatory state and ovarian fibrosis.Hs-CRP may be a po-tential therapeutic target for T2DM patients with PCOS.关键词
司美格鲁肽/2型糖尿病/多囊卵巢综合征/超敏C反应蛋白/Ⅳ型胶原蛋白Key words
Semaglutide/Type 2 diabetes/Polycystic ovary syndrome/Hypersensitive C-reactive protein/Type Ⅳ collagen分类
医药卫生引用本文复制引用
张文龙,魏东,郑莉..司美格鲁肽对2型糖尿病合并多囊卵巢综合征患者血清超敏C反应蛋白及Ⅳ型胶原蛋白的影响[J].川北医学院学报,2023,38(12):1639-1642,4.基金项目
四川省卫生健康委员会科研项目(20PJ201) （20PJ201）
