川北医学院学报2023，Vol.38Issue(12)：1664-1667,4.DOI:10.3969/j.issn.1005-3697.2023.12.018
肠道菌群水平与早产极低出生体重新生儿坏死性小肠结肠炎预后的相关性
Correlation analysis between intestinal flora level and prognosis of necro-tizing enterocolitis in premature very low birth weight newborns
摘要
Abstract
Objective:To analyze the correlation between intestinal flora level and prognosis of necrotizing enterocolitis(NEC)in premature very low birth weight newborns.Methods:105 premature very low birth weight newborns with NEC were selected and as-signed to the NEC group.According to the prognosis of the children,the surviving children were included in the survival group(n =74)and the dead children were included in the death group(n =31).At the same time,30 premature very low birth weight infants without NEC were selected as the control group.The laboratory indicators,inflammatory factor,and intestinal flora levels were compared between NEC group and the control group,and the intestinal flora and inflammatory factors levels after treatment were compared between the two groups of NEC children.Results:The fecal occult blood,HCO3-<21 mmol/L,positive blood culture,C-reactive protein>10 mg/L,platelet count>100×109/L,white blood cell count<5×109/L and white blood cell count>20×109/L in NEC group were higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of interleukin-1β(IL-1β),IL-6,IL-10 and tumor necrosis factor-α(TNF-α)in NEC group were higher than those in control group(P<0.05).The abundance of scle-renchyma,Clostridium and Shannon index in NEC group were higher than those in the control group,while the abundance of Proteobac-teria and γ-Proteobacteria were all lower than those in the control group,with statistical significance(P<0.05).Of the105 children in NEC group,74 survived and31 died,with a mortality rate of 29.52%.The ratio of fecal occult blood,HCO3-<21 mmol/L,positive blood culture,C-reactive protein>10 mg/L,white blood cell count<5×109/L,white blood cell count>20×109/L in survival group was lower than that in death group,and its IL-1β,IL-6,IL-10 and TNF-α were lower than those in death group.The abundance of sclerenchyma,Clostridium and Shannon index in survival group were lower than those in the death group,and the abundance of pro-teobacteria and γ-proteobacteria in survival group were higher than those in death group,and the differences were statistically significant(P<0.05).Conclusion:Premature very low birth weight infants with NEC generally have abnormal intestinal function,blood routine related indexes,inflammatory reaction and intestinal flora imbalance,and the more significant these changes are,the worse the prognosis of the infants is.关键词
肠道菌群/极低出生体重/坏死性小肠结肠炎/预后Key words
Intestinal flora/Very low birth weight/Necrotizing enterocolitis/Prognosis分类
医药卫生引用本文复制引用
贾益,应海燕,李少芳..肠道菌群水平与早产极低出生体重新生儿坏死性小肠结肠炎预后的相关性[J].川北医学院学报,2023,38(12):1664-1667,4.基金项目
陕西省西安市科技计划项目(20YxYJ0006) （20YxYJ0006）
