川北医学院学报2023，Vol.38Issue(12)：1668-1671,4.DOI:10.3969/j.issn.1005-3697.2023.12.019
血清转化生长因子β1与白细胞介素6水平对原发性干燥综合征并发神经系统病变的预测价值
Predictive value of serum TGF-β1 and IL-6 levels in the evaluation of pri-mary Sjögren's syndrome complicated with nervous system lesions
摘要
Abstract
Objective:To investigate the predictive value of serum transforming growth factor β1(TGF-β1)and interleukin-6(IL-6)levels in the evaluation of primary Sjögren's Syndrome(pSS)complicated with neurological lesions.Methods:80 patients with pSS were selected as the research objects,including 26 patients with neurological lesions(observation group)and 54 patients without neurological lesions(control group).The general data,pathological features,related biochemical indicators and autoantibody character-istics of the two groups were compared.Multivariate Logistic regression analysis was used to analyze the factors influencing the occur-rence of neurological disorders in pSS,and ROC curve analysis was used to analyze the predictive value of TGF-β1 and IL-6 for pSS complicated with neurological lesions was evaluated.Results:Compared with the control group,the observation group had shorter course of disease,lower incidence of xerostomia and xerophthalmia,higher ESSDAI score,higher levels of TGF-β1 and IL-6,and lower levels of complement C4(P<0.05).Multivariate Logistic regression analysis showed that TGF-β1 and IL-6 were independent risk factors for pSS complicated with nervous system lesions(OR =1.759,1.791,P<0.05).ROC curve analysis showed that the area under the curve of TGF-β1,IL-6 and their combination in predicting pSS complicated with neurological lesions was 0.882,0.868 and 0.946,respective-ly,and the combination of the two had the highest predictive value(P<0.05).Conclusion:Serum TGF-β1 and IL-6 are closely relat-ed to the occurrence of neurological diseases,which can be used as potential biomarkers for pSS complicated with neurological diseases,and provide an important basis for early diagnosis and treatment.关键词
原发性干燥综合征/神经系统病变/转化生长因子β1/白细胞介素-6/诊断Key words
Primary Sjögren's syndrome/Nervous system diseases/Transforming growth factor β1/Interleukin-6/Diagnosis分类
医药卫生引用本文复制引用
唐海,龚向瑶,张婷..血清转化生长因子β1与白细胞介素6水平对原发性干燥综合征并发神经系统病变的预测价值[J].川北医学院学报,2023,38(12):1668-1671,4.基金项目
江苏省徐州市卫生健康委科技项目青年项目(XWKYHT20220138) （XWKYHT20220138）
徐州市卫生健康委科技项目面上项目(XWKYHT20210583) （XWKYHT20210583）
