川北医学院学报2023，Vol.38Issue(12)：1672-1675,4.DOI:10.3969/j.issn.1005-3697.2023.12.020
超声脐动脉血流参数联合唐氏筛查对胎儿生长受限的预测价值
Predictive value of ultrasound umbilical artery blood flow parameters combined with Down's screening for fetal growth restriction
摘要
Abstract
Objective:To explore the predictive value of ultrasound umbilical artery blood flow parameters combined with Down's screening for fetal growth restriction(FGR).Methods:86 pregnant women who were regularly examined and diagnosed with FGR were selected as the observation group,and 86 normal pregnant women who were examined during the same period were selected as the con-trol group.All pregnant women underwent Down's screening and color Doppler ultrasonography.The differences of Down's screening in-dexes[alpha-fetoprotein(AFP),free β-human chorionic gonadotropin(β-hCG)and free estriol(uE3)]and ultrasonic umbilical ar-tery blood flow parameters[pulsatility index(PI),resistance index(RI),end-systolic velocity(PSV),end-diastolic velocity(EDV),time-average peak velocity(TAmax),and PSV/EDV(S/D)value]were compared between the two groups.Logistic regression analysis was used to establish the independent predictive factors of FGR,and the receiver operating characteristic(ROC)curve was used to ver-ify the predictive efficacy of the indexes.Results:There was no statistically significant difference between the two groups in terms of age,previous pregnancy,and previous birth(P>0.05).The gestational age of delivery and neonatal weight in the observation group were lower than those in the control group(P<0.05).The ultrasonic umbilical artery blood flow parameters PI,RI and S/D in the ob-servation group were higher than those in the control group(P<0.05),EDV and TAmax in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in PSV between the two groups(P>0.05)AFP and β-hCG in the observation group were higher than those in the control group,and uE3 was lower than that in the control group(P<0.05).Logistic regression analysis showed that PI,RI,S/D,β-hCG and uE3 had high predictive value for FGR(P<0.05).The ROC curve showed that the combined detection had the highest predictive value,with AUC of 0.970,95%CI of 0.933～0.990,sensi-tivity and specificity of 89.54%and96.52%,respectively.Conclusion:Ultrasound umbilical artery blood flow parameters and Down's screening indicators have good predictive value for FGR,and the combined use of the two can further improve the predictive efficiency.关键词
超声/脐动脉血流参数/唐氏筛查/胎儿生长受限/甲胎蛋白/人绒毛膜促性腺激素Key words
Ultrasound/Umbilical artery blood flow parameters/Down's screening/Fetal growth restriction/Alpha-fetoprotein/Human chorionic gonadotropin分类
医药卫生引用本文复制引用
李婷婷,王磊,王巧莉..超声脐动脉血流参数联合唐氏筛查对胎儿生长受限的预测价值[J].川北医学院学报,2023,38(12):1672-1675,4.基金项目
山西省大同市重点研发计划项目(2020077) （2020077）
