摘要
Abstract
Objective:To explore the effects of parenteral nutrition support with structured fat emulsion on postoperative recovery of gastrointestinal function,immune function and liver function in patients with gastric cancer.Methods:A retrospective analysis was performed on the clinical data of 186 patients with gastric cancer who underwent surgical treatment,including 95 cases in group A(structured fat emulsion)and 91 cases in group B(medium/long chain fat emulsion).After 6 d of parenteral nutrition support,the nu-tritional indicators,gastrointestinal hormones,inflammatory indicators,liver function,immune function levels,and adverse reactions were compared between the two groups.Results:After 6 d of parenteral nutrition support,levels of serum total protein(TP),albumin(Alb),transferrin(Trf)and prealbumin(Palb)in group A were higher than those in group B(P<0.05).The levels of plasma motilin(MOT),gastrin(GAS),pepsinogen Ⅰ(PG Ⅰ)and PG Ⅰ/PG Ⅱ in group A were higher than those in group B(P<0.05).The levels of serum CD3+,CD4+ and CD4+/CD8+ in group A were higher than those in group B(P<0.05),levels of interleukin 6(IL-6),tumor necrosis factor α(TNF-α)and C-reactive protein(CRP)in group A were lower than those in group B(P<0.05),and levels of ala-nine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and direct bilirubin(DBIL)in group A were lower than those in group B(P<0.05).The difference in incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:The application of structured fat emulsion in parenteral nutrition can improve nutritional status of patients after gastric cancer surgery,accelerate the recovery of gastrointestinal function,alleviate inflammatory response and improve im-mune function,with low risk of postoperative liver dysfunction.关键词
胃癌/肠外营养/结构脂肪乳/免疫功能/肝功能Key words
Gastric cancer/Parenteral nutrition/Structural fat emulsion/Immune function/Liver function分类
医药卫生
