磁共振成像2023，Vol.14Issue(12)：121-126,6.DOI:10.12015/issn.1674-8034.2023.12.021
乳腺癌化疗相关认知障碍患者的脑结构及静息态功能MRI研究进展
Research progress of brain structure and resting-state functional MRI in patients with breast cancer chemotherapy-related cognitive impairment
摘要
Abstract
Chemotherapy-related cognitive impairment(CRCI)is common among breast cancer patients after chemotherapy.More and more evidence shows that CRCI is mainly due to changes in the brain structure and function.MRI technology can reveal the reduction of gray matter volume/density,the decrease of cortical thickness,the destruction of white matter microstructure,and the abnormalities in brain function or network connectivity.This article aims to review the research on the CRCI of breast cancer using gray matter,white matter structural imaging and resting-state functional MRI(rs-fMRI).It mainly includes three dimensional T1-weighted imaging and diffusion tensor imaging(DTI)on study gray matter and white matter abnormalities,as well as the changes in brain amplitude of low frequency fluctuation(ALFF),regional homogeneity(ReHo),functional connectivity(FC)and brain networks observed in rs-fMRI.To evaluate the association between neuroimaging markers and cognitive function in the trajectory of breast cancer chemotherapy,explore the neurobiological mechanism of CRCI,and provide relatively objective neuroimaging markers for CRCI.关键词
乳腺癌/化疗相关认知障碍/磁共振成像/结构磁共振成像/功能磁共振成像Key words
breast cancer/chemotherapy-related cognitive impairment/magnetic resonance imaging/structural magnetic resonance imaging/functional magnetic resonance imaging分类
医药卫生引用本文复制引用
曹帅男,陈飞,戴真煜..乳腺癌化疗相关认知障碍患者的脑结构及静息态功能MRI研究进展[J].磁共振成像,2023,14(12):121-126,6.基金项目
Scientific Research Project of Clinical College of Jiangsu Medical Vocational College(No.20229104,20229131). 江苏医药职业学院临床学院科研项目(编号:20229104、20229131) （No.20229104,20229131）
