重庆医学2023，Vol.52Issue(23)：3560-3566,7.DOI:10.3969/j.issn.1671-8348.2023.23.007
基于血液学参数的急性高原反应潜在预测指标的筛查分析
Screening analysis of potential predictors of acute mountain sickness based on hematological parameters
摘要
Abstract
Objective The pathogenesis of acute mountain sickness(AMS)is still unclear.This study intends to continuously record the changes of physiological parameters of the Han population in the plain after high altitude exposure,and screen out the difference between AMS and high altitude acclimatization.Methods A total of 46 healthy Han people in the plain were recruited to establish a study cohort.The basic physiological and hematological parameters were measured at the time of in the plain(500 m above sea level,CQ),on the second day(LS1),the 23rd day(LS2),the 44th day(LS3)and the 65th day(LS4)after reaching the plateau.According to the 2018 version of the Louise Lake Acute Mountain Sickness Scoring System(LLS)scale score at LS2,they were divided into the AMS group and the non-AMS group,and the differences and continuous changes of parameters between groups were analyzed.Results At any time point,there was no significant difference in basic physiological and hematological parameters such as oxygen saturation,heart rate(HR),blood pressure(BP),red blood cell count(BRC),hemoglobin(Hb),and hematocrit(HCT)between the two groups(P＞0.05).Among the blood biochemical parameters,only albumin(ALB)was statistically significant at the time of LS2 and LS3 between the AMS group and the non-AMS group(P＜0.05),and the in-crease of ALB was significantly correlated with the decrease of AMS incidence(OR=0.676,95％CI:0.511-0.894,P=0.006).Conclusion Blood oxygen saturation,BRC,hemoglobin level Hb,Hb may have no predictive value for AMS,while ALB may be a good predictor for AMS,and its changes may play an important role in a-voiding AMS and promoting high altitude acclimatization.关键词
急性高原反应/血液指标/清蛋白/高原习服Key words
acute mountain sickness/blood indicators/albumin/high altitude acclimatization分类
医药卫生引用本文复制引用
叶梓,刘鑫源,陈郁,罗勇军..基于血液学参数的急性高原反应潜在预测指标的筛查分析[J].重庆医学,2023,52(23):3560-3566,7.基金项目
国家自然科学基金面上项目(42377466) （42377466）
科技部第二次青藏高原综合科学考察研究专题(2019QZKK0607). （2019QZKK0607）
