重庆医学2023，Vol.52Issue(23)：3567-3571,5.DOI:10.3969/j.issn.1671-8348.2023.23.008
全程热疗治疗鼻咽癌颈部转移淋巴结的疗效及对免疫功能的影响
Efficacy of whole course hyperthermia on cervical metastatic lymph nodes of nasopharyngeal carcinoma and its effects on immune function
摘要
Abstract
Objective To study the short-term efficacy of combined cervical metastatic lymph nodes hy-perthermia during locally advanced nasopharyngeal carcinoma induction chemotherapy and concurrent chemo-radiotherapy and its effect on peripheral blood lymphocyte subsets.Methods Sixty patients with pathological-ly diagnosed nasopharyngeal carcinoma in this hospital from July 2021 to July 2022 were collected as the study subjects and divided into the observation group(induction chemotherapy+concurrent chemoradiotherapy combined with hyperthermia)and control group(induction chemotherapy+concurrent chemoradiotherapy),30 cases in each group.The general information,short term efficacy,EB virus(EBV)DNA level,adverse reac-tions occurrence,peripheral blood lymph cell subsets and hot shock protein 90α(HSP90α)were recorded and compared between the two groups.Results Compared with the control group,the objective remission rate in the observation group was higher(100.0％vs.90.0％),the EBV positive rate after induction chemotherapy was lower(20.0％vs.46.7％),the occurrence rate of ≥3 grade radiation dermatitis was higher(30.0％vs.6.7％),the level of natural killer(NK)cells after radiotherapy was increased[(25.89±5.53)％vs.(19.18±6.41)％],the HSP90α level after treatment was increased[(91.19±9.18)ng/mL vs.(67.22± 11.02)ng/mL],and the differences were statistically significant(P＜0.05).Compared with before treatment,the levels of CD3+,CD4+,CD4+/CD8+after radiotherapy in the observation group were decreased,the levels of CD3+,CD4+,CD4+/CD8+in the control group were decreased,but the differences between the two groups were not statistically significant(P＜0.05),while the proportion of peripheral blood NK cells in the experi-mental group was significantly increased compared with the control group(P＜0.05).Conclusion Hyper-thermia canimprove the local control of nasopharyngeal carcinoma cervical lymph node metastasis and improve the immune function.关键词
热疗/同步放化疗/鼻咽癌/免疫功能/淋巴细胞亚群Key words
hyperthermia/concurrent chemoradiotherapy/nasopharyngeal carcinoma/immune func-tion/lymphocyte subsets分类
医药卫生引用本文复制引用
罗焱,谢悦,李晓宇,闫瑾,刘德清,王雨晴,杨丽娜,王颖..全程热疗治疗鼻咽癌颈部转移淋巴结的疗效及对免疫功能的影响[J].重庆医学,2023,52(23):3567-3571,5.基金项目
国家自然科学基金项目(82272755) （82272755）
重庆市自然科学基金项目(2022NSCQ-MSX0706) （2022NSCQ-MSX0706）
重庆市沙坪坝区科技局决策咨询与管理创新项目(Jcd202279). （Jcd202279）
