重庆医学2023，Vol.52Issue(23)：3572-3576,5.DOI:10.3969/j.issn.1671-8348.2023.23.009
20例原发性胃腺鳞癌临床病理学特征分析
Analysis of clinicopathological characteristics in 20 cases of primary gastric adenosquamous carcinoma
摘要
Abstract
Objective To investigate the clinical manifestations,pathological diagnosis,treatment meth-od and prognosis of primary gastric adenosquamous carcinoma.Methods The clinical data of 20 patients with primary gastric adenosquamous carcinoma receiving the treatment in this hospital from January 1,2013 to No-vember 30,2022 were retrospectively analyzed,and their clinicopathological characteristics and prognosis were analyzed.Results Among the 20 patients,14 cases were male and 6 cases were female,with a median age of 59(36,74)years old.Upper abdominal discomfort,pain and weight loss were the main clinical symptoms.Ser-um carbohydrate antigen 19-9(CA19-9)levels were elevated in some patients.The image examination indica-ted the gastric occupation.Among 20 cases,the tumors were most common in the lower third of the stomach(14 cases),followed by the upper third(1 case)and the middle third(5 cases).The most common tumors were in the lower one-third(14 cases)of the stomach,followed by the middle one-third(5 cases)and upper one-third(1 case).In histomorphology,the gastric tumor cells contained two components,adenocarcinoma and squamous cell carcinoma,and squamous cell carcinoma accounted for more than 25％of tumor cells.Immuno-histochemistry showed that the partial tumor cells of adenocarcinoma expressed CK8/18 and partial tumor cells of squamous cell carcinoma expressed p40.All 20 cases performed the surgical treatment.Only 6 cases survived and the others died of tumor recurrence or metastasis.The adenosquamous carcinoma proportion and Ki-67 were correlated with the prognosis in the patients with gastric adenosquamous carcinoma(P＜0.05).The survival curve constructed by the Kaplan-Meier method showed that when the proportion of squamous carcinoma was more than 35％,the prognosis of the patients was good.Conclusion Primary gastric adenosquamous carcinoma,mainly composed of adenocarcinoma,may be correlated with a higher risk of metastasis.关键词
胃肿瘤/腺鳞癌/生存分析/增殖指数/预后Key words
gastric tumor/adenosquamous cell carcinoma/survival analysis/value-added index/prognosis分类
医药卫生引用本文复制引用
何亚运,史晓辰,高依莎..20例原发性胃腺鳞癌临床病理学特征分析[J].重庆医学,2023,52(23):3572-3576,5.基金项目
海军军医大学第一附属医院医学基础研究专项青年培育项目(2021JCQN05). （2021JCQN05）
