重庆医学2023，Vol.52Issue(23)：3577-3582,6.DOI:10.3969/j.issn.1671-8348.2023.23.010
吸烟与急性心肌梗死患者内皮细胞源微粒表达水平相关性研究
Correlation between smoking and endothelial cell-derived particle expression levels in patients with acute myocardial infarction
摘要
Abstract
Objective To study the correlation between smoking and levels of endothelial microparticles(EMPs)in patients with acute myocardial infarction(AMI).Methods A total of 74 patients with AMI who were admittedto Xinjiang Uighur Autonomous Region People's Hospital from January 2020 to December 2020 were selected to be included in AMI group,and 72 patients with non-AMI chest tightness/pain were included in the non-AMI group.The general information of the patients in the two groups was collected,and the pe-ripheral venous bloodof the two groups was extracted.The EMPs levels and other clinical biochemical indexes were detected by flow cytometry.Results The proportion of males,WBC,proportion of smokers,and EMPslevel in patients in the AMI group were higher than those in the non-AMI group,and the difference was statistically significant(P＜0.05).The results of univariate logistic analysis showed that gender,WBC,EMPs,and smoking were risk factors for the development of AMI,and the difference was statistically signifi-cant(P＜0.05).Further multifactorial logistic regression results showed that high levels of elevated EMPs and smoking were independently associated with the occurrence of AMI.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of EMPs in predicting AMI,and the area under the curve(AUC)between EMPs and AMI was 0.877(95％CI:0.824-0.929,P＜0.001).Logistic regression with EMPs as the dependent variable showed that low high-density lipoprotein(HDL)levels and smoking were independent risk factors for increased levels of EMPs.Conclusion High levels of EMPs and smoking were in-dependently associated with the development of AMI,and smoking-induced release of EMPs may be one of the reasons why patients are more likely to develop AMI.关键词
吸烟/急性心肌梗死/微粒/内皮细胞Key words
smoking/acute myocardial infarction/particles/endothelial cells分类
医药卫生引用本文复制引用
佧米莱·赛伊提江,吐尔孙阿依·依斯米提拉,刘米莉,穆叶赛·尼加提..吸烟与急性心肌梗死患者内皮细胞源微粒表达水平相关性研究[J].重庆医学,2023,52(23):3577-3582,6.基金项目
新疆维吾尔自治区自然科学基金项目(2019D01C104). （2019D01C104）
