重庆医学2023，Vol.52Issue(23)：3609-3614,3619,7.DOI:10.3969/j.issn.1671-8348.2023.23.016
维生素D与性激素及其受体对男性临床孤立综合征复发的预测价值
Predictive value of vitamin D,sex hormones and their receptors on relapse in male patients with clinically isolated syndrome
摘要
Abstract
Objective To investigate the predictive value of vitamin D,sex hormones and their receptors in the development and regression of male patients with clinical isolated syndrome(CIS).Methods A total of 40 male CIS patients were included in the CIS group and 30 healthy subjects matched in age and long-term res-idence were included in the control group.The levels of vitamin D[1,25(OH)2D2 and 1,25(OH)2D3]inpe-ripheral blood of the included individuals and the first relapsed multiple sclerosis patients(MS group)were detected by ultra-high-performance liquid chromatography-tandem mass spectrometry.The levels of testoster-one(T),progesterone(P),and estradiol(E2)in peripheral blood were detected by electrochemiluminescence.Estrogen receptor(ERα,ERβ),androgen receptor(AR)and vitamin D receptor(VDR)levels in lymphocyte supernatant were detected by enzyme-linked immunosorbent assay(ELISA).Results After a median follow-up of 31.5 months,29 patients(72.5％)with CIS were converted to multiple sclerosis.Compared with pa-tients with non-recurrent CIS patients,patients with multiple sclerosis had a younger age of onset and were prone to positive oligoclonal bands.Compared with HC group,vitamin D levels were reduced in CIS patients,and the difference was statistically significant(P＜0.05).When CIS patients reverted to multiple sclerosis,se-rum levels of E2,ERα,and ERβ were elevated compared with those before relapse,and the levels of testosteroneand AR were decreased,and the difference was statistically significant(P＜0.05).Correlation analysis showed no correlation between peripheral blood levels of vitamin D,sex hormones and their receptors and EDSS in CIS patients.Conclusion Male CIS patients with younger onset age and positive oligoclonal bands are prone to transition to multiple sclerosis.The decrease of vitamin D level may be associated with the onset of male CIS.Vitamin D,sex hormones,and their receptors have no predictive value in the conversion of CIS to multiple sclerosis.关键词
临床孤立综合征/维生素D/多发性硬化/雌二醇/睾酮Key words
clinically isolated syndrome/vitamin D/multiple sclerosis/estradiol/progesterone分类
医药卫生引用本文复制引用
梁军利,张滢,梁叶源,丘小慧,梁津瑜,唐玉兰..维生素D与性激素及其受体对男性临床孤立综合征复发的预测价值[J].重庆医学,2023,52(23):3609-3614,3619,7.基金项目
2020年广西高校中青年教师科研基础能力提升项目(2020KY03041) （2020KY03041）
2021年广西医疗卫生适宜技术开发与推广应用项目(S2020015) （S2020015）
2019年广西医疗卫生适宜技术开发与推广应用项目(S2019093). （S2019093）
