重庆医学2023，Vol.52Issue(23)：3632-3637,6.DOI:10.3969/j.issn.1671-8348.2023.23.020
急性白血病患儿化疗期症状和身体功能的潜在转变分析
Analysis of potential changes in symptoms and physical function during chemotherapy in children with acute leukemia
徐艳华 1沈南平1
作者信息
- 1. 上海交通大学医学院附属上海儿童医学中心护理部,上海 200127
- 折叠
摘要
Abstract
Objective To explore the potential transformation patterns and influencing factors of symp-toms and physical function in children with acute leukemia during chemotherapy.Methods A total of 109 children with acute leukemia who were treated in a children's hospital in Shanghai from March 2021 to Sep-tember 2022 were selected as the study subjects.The general information questionnaire and the Chinese ver-sion of the Patient-Reported Outcome Measurement Information System(C-C-Ped-PROMIS)were used to e-valuate the symptoms and physical function at 1-3 days before chemotherapy(T1)and 7-17 days after chemotherapy(T2).Potential transition analysis was used for data processing.Results Three similar latent class features were identified at T1 and T2:the low distress group(T1:25.7％;T2:23.8％),the moderate dis-tress group(T1:42.2％;T2:43.6％)and the high distress group(T1:32.1％;T2:32.7％).The probability of maintaining the original group in the middle distress group and the high distress group was 60.3％and 72.3％,respectively.The probability of transition from the low distress group to the medium distress group and the high distress group was 40.2％and 22.3％,respectively.The probability of transition from the middle dis-tress group to the high distress group was 37.0％.In this study,16 cases(14.7％)were transitioned from the low distress group or the middle distress group to the high distress group,and there was a statistically signifi-cant difference in the distribution of daily fatigue within seven days at T1(P＜0.05).Conclusion The symp-toms and physical function of children with acute leukemia during chemotherapy are heterogeneous.The fa-tigue assessment at baseline can provide reference information for potential state transfer.Medical staff should give accurate supportive intervention for different stages of chemotherapy.关键词
儿童/白血病/患者报告结局/潜在剖面分析/潜在转变分析Key words
children/leukemia/patient-reported outcomes/potential profile analysis/potential transfor-mation analysis分类
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徐艳华,沈南平..急性白血病患儿化疗期症状和身体功能的潜在转变分析[J].重庆医学,2023,52(23):3632-3637,6.
