重庆医学2023，Vol.52Issue(23)：3658-3664,7.DOI:10.3969/j.issn.1671-8348.2023.23.025
FLT3抑制剂治疗急性髓系白血病的研究进展
Advances in the treatment of acute myeloid leukaemia with FLT3 inhibitors
摘要
Abstract
Acute myeloid leukaemia(AML)is a highly heterogeneous haematological malignancy,in which FMS like tyrosine kinase 3(FLT3)gene mutation is one of the common gene mutations in AML.Pa-tients with FLT3 mutations have a high relapse rate and poor prognosis,making FLT3 one of the most prom-ising targets for the treatment of AML.At present,the first and second generation inhibitors have entered clinical research successively,among which Midostaurin,Giletitinib,and Quizartinib have been approved for the treatment of AML patients.The combination of FLT3 inhibitors with standard chemotherapeutic drugs can improve the remission rate of the disease,and also have better efficacy in subsequent maintenance therapy or transplant patients,which can improve the overall prognosis of patients.However,some patients may devel-op drug resistance.Developing new FLT3 inhibitors or combining FLT3 inhibitors with other drugs can reduce the development of drug resistance.This article reviewed the research progress of common FLT3 inhibitors in the treatment of AML,in order to provide reference for clinical practice.关键词
急性髓系白血病/FMS样酪氨酸激酶3抑制剂/靶向治疗/综述Key words
acute myeloid leukemia/FMS-like tyrosine kinase-3 inhibitor/targeted therapy/review分类
医药卫生引用本文复制引用
令狐顺,肖青,王利..FLT3抑制剂治疗急性髓系白血病的研究进展[J].重庆医学,2023,52(23):3658-3664,7.基金项目
重庆市科卫联合医学科研项目(2018ZDXM001). （2018ZDXM001）
