大连工业大学学报2023，Vol.42Issue(6)：397-401,5.DOI:10.19670/j.cnki.dlgydxxb.2023.6007
壳聚糖基温敏型水凝胶颗粒的制备及其缓释性能
Preparation of thermosensitive hydrogel microspheres from chitosan for controlled drug delivery
摘要
Abstract
Temperature-sensitive chitosan/β-sodium glycerophosphate composite hydrogel microcapsules were prepared by emulsification-chemical crosslinking method.The hydrogel microcapsules were characterized by FT-IR and SEM.The encapsulation ability of chitosan hydrogel microcapsules to nicotinamide,one type of the cosmetic active substance,was evaluated with the aim of evaluating the water absorption swelling property,drug loading and slow-release ability of microcapsules.The results showed the encapsulation rate of microcapsules to nicotinamide was up to 91.9％under the conditions of 1∶4 volume ratio of water phase to oil,2.0％mass fraction of chitosan and 1.250％mass fraction of glutaraldehyde.The release rate of nicotinamide could reach 92.3％after 24 h,which confirmed the excellent slow-release ability of microcapsules.关键词
壳聚糖/温度响应/凝胶颗粒/烟酰胺Key words
chitosan/temperature response/hydrogel microspheres/nicotinamide分类
轻工纺织引用本文复制引用
翟晓毓,王碧瑶,李沅,谭凤芝,刘兆丽..壳聚糖基温敏型水凝胶颗粒的制备及其缓释性能[J].大连工业大学学报,2023,42(6):397-401,5.基金项目
辽宁省教育厅基本科研项目(LJKMZ20220893). （LJKMZ20220893）
