大连工业大学学报2023，Vol.42Issue(6)：420-426,7.DOI:10.19670/j.cnki.dlgydxxb.2023.6022
胶原/氧化葡聚糖/葡萄糖酸锌载药水凝胶的制备及性能
Preparation and property of collagen/oxidized dextran/zinc gluconate hydrogel for drug delivery
摘要
Abstract
A type of bacteria-responsive collagen-based drug-loaded hydrogel for the delivery of aminoglycosides was constructed,in which type Ⅰ collagen was used as the matrix,oxidized dextran and zinc gluconate were used as the cross-linker and amikacin was used as the model drug.The results of swelling,degradation resistance and dynamic rheological analysis showed that the Schiff base reaction between oxidized dextran and the free amino group of collagen side chain and the coordination between Zn2+and the carboxyl group of collagen side chain could reduce the swelling property of the modified collagen hydrogel,improve its mechanical property and resistance to enzymatic degradation.The results of SEM showed that the network structure of modified collagen fibers was elevated as a result of crosslinking.The release kinetics of amikacin from the drug-loaded hydrogel in the medium with pH of 7.4 and 5.0 were compared.These two mediums represented the healthy condition and the bacterial infections in vivo.The results showed that the release of amikacin at pH 5.0 was faster,which confirmed the bacterial responsiveness of the drug-loaded hydrogel.In addition,the growth of Escherichia coli and Staphylococcus aureus were inhibited by this drug-loaded hydrogel,confirming its bacteriostatic effect.关键词
胶原蛋白/氧化葡聚糖/载药水凝胶/pH响应性能Key words
collagen/oxidized dextran/drug-loaded hydrogel/pH responsive performance分类
轻工纺织引用本文复制引用
朱志勉,匡卫,田荟琳,段炼..胶原/氧化葡聚糖/葡萄糖酸锌载药水凝胶的制备及性能[J].大连工业大学学报,2023,42(6):420-426,7.基金项目
国家自然科学基金青年科学基金项目(22008201). （22008201）
